摘要
[目的]收集17例中枢神经系统原发性淋巴瘤 ,对其临床病理特点及免疫组化染色特征进行探讨。[方法]标本采用常规石蜡切片、HE染色及SP法免疫组化染色 ,光镜观察。[结果]17例患者中男性12例 ,女性5例 ;中位年龄50岁。17例中肿瘤位于顶叶5例 ,额叶4例 ,颞叶和基底节区各3例 ,小脑2例。16例肿瘤细胞呈弥漫围绕血管分布 ,仅1例在肿瘤内可见部分滤泡形成。17例肿瘤细胞均为LCA阳性表达 ,其中16例L26阳性 ,1例UCLH1阳性。[结论]PCNSL好发于50岁左右男性患者 ,以顶、额叶多见。镜下见肿瘤细胞多呈弥漫围绕血管分布。免疫组化染色证明肿瘤多为B细胞性淋巴瘤 。
To investigate the clinicopathology and immunohistochemistry characters of primary central nervous system lymphoma(PCNSL)Routine paraffin slides stained with HE and SP immunohistochemistry were studied under optical microscope in 17 cases with PCNSLOf the 17 cases,there were 12 male and 5 femalThe mean age was 493The neoplasm was located in lobus parietalis(5 cases),lobus frontalis(4 cases),lobus temporalis(3 cases),basal ganglia(3 cases) and cerebellum(2 cases)Microscopically,all the lymphoma cells in the 17 cases(16/17) were diffusely arranged in sheets without formation of lymphoid follicle except in one case whose lymphoma cells formed indistinct lymphoid follicularFor immunohistochemistry stain,lymphoma cells positive LCA expression in all the casesAmong them,16 cases L26 positive,and 1 case UCLH1 positive[Conclusions]PCNSL predominately tended to afflict around 50year old male patientsIt is located most in lobus frontalis,lobus parietalisLymphoma cells often distributed around the capillaries in cerebrum microscopicallyThe immunohistochemistry stain revealed that the most common type of PCNSL is B cell lymphoma,and T cell lymphoma is rare
基金
国家教委留学回国人员科研启动基金!(教外司留[1997]436号 )
南京市留学回国人员科研基金资助
