摘要
[目的]研究枢丹和格拉司琼在甲状腺癌根治术患者术后的抗呕吐作用 ,并比较两者对术后恶心呕吐(PONV)的预防效果。[方法]选择甲状腺癌根治术患者90例 ,随机分为枢丹组(4mg,n=30)、格拉司琼组(3mg,n=30)和安慰剂组(生理盐水 ,n=30) ,诱导前静推枢丹或格拉司琼或安慰剂 ,双盲法观察术后24小时恶心、呕吐的发生率。[结果]枢丹组恶心、呕吐的发生率(23 % ,17 %)与格拉司琼组(20 % ,13 %)无显著性差异(P>0 05) ,用药组恶心、呕吐的发生率明显低于安慰剂组(67 % ,57 %;P<0 01)。[结论]枢丹和格拉司琼均能有效地预防甲状腺癌根治术后的恶心、呕吐 ,两者对PONV的预防效果无明显差别。
To investigate the antiemetic effects of Ondansetron and Granisetron on nausea and vomiting in the patients after radical thyroidectomy of thyroid carcinomaNinty patients with thyroid carcinoma,scheduled for radical thyroidectomy were randomly allocated to receiving Ondansetron(4mg,n=30),Granisetron(3mg,n=30) or placebo(normal saline,n=30)All these drugs were injected intravenously before inductionAntiemetic effect was observed 24 hours after operation with doubleblind methodThe occurrant rate of nausea and vomiting was not significantly different between Ondansetron group(23%,17%) and Granisetron group(20%,13%)(P>005),but that in both groups decreased significantly in comparison with placebo group(67%,57%)(P<001).[Conclusion]Ondansetron and Granisetron can effectively prevent nausea and vomiting after radical thyroidectomy.There is no difference of antiemetic effects between Ondansetron and Granisetron
