摘要
目的 探讨西帕依固龈液在体外抑制牙龈周围可疑致病菌的作用和观察体内防治牙龈炎的疗效。方法 采用琼脂稀释方法测定西帕依固龈液在体外对牙龈卟啉单胞菌、具核梭杆菌和中间普雷沃菌的最低抑菌浓度（MIC）;选择112例单纯性牙龈炎患者,随机平均分为研究组和对照组,研究组（56例）给予西帕依固龈液漱口治疗,对照组（56例）给予不含有效成分的含漱液漱口治疗,两组均治疗7d,观察两组患者治疗前后龈沟出血指数（SBI）与菌斑指数（PLI）变化。结果 两组在治疗前SBI和PLI差异无统计学意义（P＞0.05）;研究组治疗后SBI和PLI均较治疗前显著降低,差异有统计学意义（P＜0.05）;对照组治疗前后SBI和PLI差异均无统计学意义（均P＞0.05）;治疗后研究组SBI和PLI数值显著低于对照组,差异有统计学意义（P＜0.05）。结论 西帕依固龈液能明显抑制牙周可疑致病菌,同时可以减少牙菌斑堆积、降低SBI,能很好的改善牙龈健康。
Objective To discuss the clinical effect of Xipayinguyinye on oral bacteria in vitro and gingivitis in vivo.Methods Took the method of agar dilution to measure the minimum inhibitory concentration（MIC）of Xipayinguyinye on Porphyromonas gingivalis（P.gingivalis）,Prevotella intermedia（P.intermedia）and Fusobacterium nucleatum（F.nucleatum）in vitro;choose 112 patients with simple gingivitis and they were randomly divided into the research group and control group.The research group（56 cases）received the treatment of Xipayiguyinye,while the control group（56 cases）received the treatment without effect components.Both groups received 7 days of treatment and then observed the changes of sulcus bleeding index（SBI）and plaque index（PLI）before and after the treatment.Results MIC of Xipayiguyinye in vitro was 1.0g/L for P.gingivalis and F.nucleatum and 0.5g/L for P.intermedia.There was no statistifically significant difference in SBI and PLI between two groups before the treatment（P＞0.05）;there was significant difference in SBI and PLI of research group before and after the treatment（P＜0.05）;there was no significant difference in SBI and PLI of control group before and after the treatment（P＞0.05）;there was significant difference in SBI and PLI in SBI and PLI between two groups after the treatment（P＜0.05）.ConclusionXipayiguyinye could prevent bacteriostasis well and decrease the accumulation of dental plaque,reduce SBI and improve the health of the gingiva in vivo.
出处
《中国基层医药》
CAS
2012年第15期2264-2265,共2页
Chinese Journal of Primary Medicine and Pharmacy
