期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Synthesis of Hirtellanine B, an Isoflavonoid with Potent Antiproliferative Effects in Cancer Cells 被引量：1

Synthesis of Hirtellanine B, an Isoflavonoid with Potent Antiproliferative Effects in Cancer Cells
原文传递
导出
摘要 We reported the first total synthesis of hirtellanine B, using oxidative coupling for the key reactions, which resulted in a high yield. The antiproliferative activities of hirtellanine B against Jurkat cells, Raji cells and K562 cells were also investigated. It was found that hirtellanine B could induce G2/M arrest and apoptosis in human lymphoid/leukemia tumor cells. We reported the first total synthesis of hirtellanine B, using oxidative coupling for the key reactions, which resulted in a high yield. The antiproliferative activities of hirtellanine B against Jurkat cells, Raji cells and K562 cells were also investigated. It was found that hirtellanine B could induce G2/M arrest and apoptosis in human lymphoid/leukemia tumor cells.
作者 郑书岩 符润中 沈征武
机构地区 School of Pharmacy Departmen of Applied Chemistry Basilea Pharmaceutica China Ltd.
出处 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2012年第7期1405-1409,共5页 中国化学（英文版）
关键词 hirtellanine B SYNTHESIS ANTIPROLIFERATION G2/M arrest cancer cell hirtellanine B, synthesis, antiproliferation, G2/M arrest, cancer cell
分类号 Q279 [生物学—细胞生物学] Q343.245 [生物学—遗传学]
  • 相关文献

参考文献11

  • 1Shou, Q. Y.; Tan, Q.; Shen, Z. W. Bioorg. Med. Chem. Lett. 2009, 19,3389.
  • 2Shou, Q. Y.; Tan, Q.; Shen, Z. W. Planta Med. 2009, 75, 1.
  • 3Shou, Q. Y.; Tan, Q.; Shen, Z. W. J. Agric. Food Chem. 2009, 57, 6712.
  • 4Zheng, S. Y.; Shen, Z. W. Tetrahedron Lett. 2010, 51, 2883.
  • 5Igarashi, Y.; Kumazawa, H.; Ohshima, T.; Satomi, H.; Terabayashi, S.; Takeda, S.; Aburada, M.; Miyamoto, K. Chem. Pharm. Bull. 2005,53,1088.
  • 6Guang, 8.; Xu, M. X.; Mo, W. S.; Chu, Y. Chem. Res. Appl. 1999, 11,525.
  • 7Nematollahi, D.; Habibi, D.; A1izadeh, A.; Hesari, M. J. Heterocyclic Chem. 2005, 42, 289.
  • 8Reichert, T. E.; Nagashima, S.; Kashii, Y.; Stan son, J.; Gao, G.; Dou, Q. P.; Whiteside, T. L. Oncogene 2000, 19,514.
  • 9Moarbess, G.; EI-Hajj, H.; Kfoury, Y.; EI-Sabban, M. E.; Lepelletier, Y.; Hermine, 0.; Deleuze-Masquefa, C.; Bonnet, P. A.; Bazarbachi, A. Blood 2008,111,3770.
  • 10Jun, D. Y.; Park, H. S.; Kim, J. S.; Kim, J. S.; Park, W.; Song, B. H.; Kim, H. S.; Taub, D.; Kim, Y. H. Toxicol. Appl. Pharm. 2008, 231, 401.

同被引文献3

引证文献1

二级引证文献2

Chinese Journal of Chemistry
2012年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部