摘要
目的对火绒草的化学成分进行分离与鉴定。方法应用硅胶柱色谱、葡聚糖凝胶柱色谱和高效液相制备色谱分离纯化,根据理化性质和波谱数据确定化合物的结构。结果从火绒草中分离得到10个化合物,分别鉴定为咖啡酸乙酯(ethyl caffeate,1)、芹菜素(apigenin,2)、对羟基苯甲酸(P-hydroxybenzoic acid,3)、原儿茶醛(protocatechuic aldehyde,4)、原儿茶酸(protocatechuic acid,5)、咖啡酸(caffeic acid,化合物6)、槲皮素(quercetin,7)、木犀草素(luteolin,8)、对羟基桂皮酸(p-hydroxy cinnamic acid,9)、阿魏酸(ferulic acid,10)。结论化合物1-3、8首次从火绒草中分离得到,化合物1-3为首次从火绒草属植物中分离得到。
Objective To isolate and identify the chemical constituents from whole plant of Leontopodium leontopodioides.Methods Compounds were isolated and purified on the silica gel,sephadex LH-20 chromatograph and RP-HPLC.The structures of chemical compounds were elucidated on the basis of spectra data.Results Ten compounds were identified as ethyl caffeate（11）,apigenin（2）,p-hydroxybenzoic acid（3）,protocatechuic aldehyde（4）,protocatechuic acid（5）,caffeic acid（6）,quercetin（7）,luteolin（8）,p-hydroxy cinnamic acid（9）and ferulic acid（10）,respectively.Conclusions Compounds 1-3,8 are isolated from L.leontopodioides for the first time,and compounds 1-3 are purified from Leontopodium for the first time.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2012年第8期606-608,639,共4页
Journal of Shenyang Pharmaceutical University
关键词
火绒草
化学成分
分离鉴定
Leontopodium leontopodioides； chemical constituent； structure elucidation
