摘要
40例慢阻肺者五肽胃泌素泌酸试验,胃粘膜屏障功能、空腹胃液胆酸及空腹血清胃泌素的测定,发现无论在低氧血症或高二氧化碳血症状态,胃酸分泌均增高,胃粘膜屏障功能亦受损,与血P_aCO_2值呈一定的正相关,胃粘膜屏障损害比胃粘膜形态学改变更早出现。慢阻肺者空腹胃液胆酸与正常人比较并未增高,空腹血清胃泌素在慢阻肺及正常人之间无显著性差异,血清胃泌素在呼衰胃损害发病过程中所起的作用尚不清楚。
Fourty patients with COPD were studied on pentagastrin test, function of gastric mu-cosal barrier, fasting gastric cholic acid and fasting serum gastrin. The results showed COPD patients with hypoxemia or hypercapnia have gastric acid secretion increased and gastric mucosal barrier's function damaged, especially in the presence of respiratory failure. A postive correlation between PaCO2 level and the damage of gastric mucosal barrier or gastric acid secretion was proved. The damage of gastric mucosal barrier's function may occur prior to visual histological changes. Fasting gastric cholic acid in COPD patients was not higher than that in control subjects (P>0.05). The result suggested that cholic acid is not an important factor in gastric damage of COPD patients. Although serum gastrin in the patients with respiratory failure was higher than that in control subjects. They had not statistical significance. The results of further study showed that gastric acid increased and gastric mucosal barrier's function decreased are responsible for upper digestive tract diseases in COPD patients. For this reasdn, it is necessary to combine antiacids with gastric niucosa-protecting agents treat the patients with severe respiratory failure, so as to prevent occurrence of peptic ulcer or hemorrhage of upper digestive tract.
出处
《中山医科大学学报》
CSCD
1990年第4期45-48,共4页
Academic Journal of Sun Yat-sen University of Medical Sciences
关键词
慢阻肺
上消化道病变
发病机制
Chronic obstructive pulmonary disease Pentagastrin test Function of gastric mucosal barrier Gastric chojic acjd Serum gastrjn
