摘要
目的观察艾司洛尔对全麻后拔管期心血管反应的影响.方法 60例ASAⅠ～Ⅱ级择期手术病人随机分为2组,对照组(A组,30例)和艾司洛尔组(B组,30例).全麻术后患者呼之睁眼,分别静脉给予等容量生理盐水(A组)和艾司洛尔0.5 mg/kg(B组),记录入室后、拔管前、拔管时、拔管后1、2、4、10 min时的心率(HR)、血氧饱和度(SpO)2、收缩压(SBP)、舒张压(DBP),并计算RPP(HR和SBP乘积).结果 A组HR和RPP于拔管时[HR(110.5±9.5)次/min,RPP 2 220±275]至拔管后4 min内[HR(102.7±14.1)次/min,RPP 1 902±220]与B组[拔管时(HR88.5±6.5)次/min,RPP 1 607±212];拔管后4 min内[HR(87.7±10.5)次/min,RPP 1 487±276]比较P<0.05,SpO2、SBP及DBP组间比较无统计学意义(P>0.05).结论艾司洛尔可防止全麻拔管引起的HR和RPP的增加,可安全、有效地抑制全麻气管拔管心血管反应.
Objective To observe the effect of esmolol on cardiovascular response to tracheal extubation. Methods Sixty patients esmolol group （group B）. normal saline （Group A） with ASA I - II were randomly divided into two groups： control group （group A） and Postoperative patients of general anesthesia were commanded to open eyes, then received and esmolol 0.5 mg/kg （Group B） , respectively. HR, SpOz, SBP and DBP were monitored and recorded before induction （baseline） , before and after extubation, and 1, 2, 4, 10 rain after extubation in all patients, and RPP were calculated. Results Compared with Group B, HR and RPP of patients in Group A increased significantly at extubating and in 4min after extubation （P 〈 0.05）. There was no difference in SpO2, SBP and DBP between two groups （P〉 0.05）. Conclusion Esmolol is effective to attenuate the increase in HR and RPP, and can inhibit the cardiovascular response to tracheal extubation effectively and safely.
出处
《昆明医学院学报》
2012年第7期100-102,共3页
Journal of Kunming Medical College
关键词
艾司洛尔
拔管
心血管反应
Esmolol
Tracheal extubation
Cardiovascular response
