摘要
目的:观察前列地尔注射液对百草枯中毒患者炎症介质和肺损伤的影响,为临床治疗提供参考。方法:30例急性百草枯中毒患者随机分为常规治疗组(对照组)和常规治疗+前列地尔注射液组(试验组),每组15例。前列地尔注射液用法:10μg加入100mL生理盐水(NS)静脉滴注,1次/d,连用7d。分别于入院当天及入院后7d测定患者血浆IL-6、IL-8、基质金属蛋白酶-9(MMP-9)浓度,行动脉血气分析和胸部X线检查,并随访生存情况。结果:与对照组比较,入院后7d试验组患者IL-6、IL-8、MMP-9浓度降低,急性肺损伤(ALI)及全身炎症反应综合症发生率降低(P<0.05);两组患者病死率差异无统计学意义(P>0.05)。结论:前列地尔注射液可减轻百草枯中毒患者炎症反应和肺损伤。
AIM： To investigate the clinical therapeutic effect of alprostadil injection on inflammatory response and lung injury in patients with paraquat poisoning and thus to improve clinical practice. METHODS. Thirty patients with paraquat poisoning were randomized into control and observation group （15 cases in each group）, where the patients in control group received routine therapy and additional 10μg alprostadil injection dissolved in 100 mL saline was administrated intravenously for 7 days in experimental group. Plasma levels of interleukine- 6, 8 and matrix metalloproteinase-9 （MMP-9） were detected; arterial blood gas analysis and chest X-ray examination were performed at the first and seventh day of admission, and mortalitycompared between the two groups. RESULTS： Compare to control group, the levels of plasma IL-6, IL-8 and MMP-9 were decreased, the incidences of acute lung injury and systemic inflammatory response syndrome were lower in experimental group at seventh day of admission （P〈 0.05）. There was no significant differences of mortality between the two groups （P〈0.05）. CONCLUSION. Alprostadil injection could protect the patients with paraquat poisoning agaist acute lung injury by attenuating inflammatory response.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2012年第8期910-914,共5页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
中毒
百草枯
肺损伤
前列地尔
Poisoning
Paraquat
Lung injury
Alprostadil
