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内皮祖细胞与肿瘤血管生成的研究进展 被引量：2

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摘要 肿瘤血管生成一直是肿瘤领域的研究热点。近几年的研究表明,内皮祖细胞(EPCs)参与肿瘤血管生成,可以在肿瘤组织内募集,并向成熟内皮细胞分化,对肿瘤生长、浸润及转移的作用不可忽视。其中血管内皮生长因子(VEGF)与VEGF受体-2(VEGFR-2)相结合是EPCs参与肿瘤血管生成的一个重要机制,抑制VEGF的通路信号可以削弱EPCs向肿瘤血管的募集和参与血管生成,也可显著地延缓肿瘤的生长。
作者 陈振波 阎萍 梁志清
机构地区 第三军医大学附属西南医院
出处 《实用妇产科杂志》 CAS CSCD 北大核心 2012年第7期533-536,共4页 Journal of Practical Obstetrics and Gynecology
基金 国家自然科学基金(编号:30801235)
关键词 内皮祖细胞 肿瘤 血管内皮生长因子 血管生成
分类号 R73 [医药卫生—肿瘤]
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同被引文献52

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实用妇产科杂志
2012年 第7期

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