摘要
目的:明确崇明地区脂肪肝的患病率及其相关危险因素。方法:采用随机整群抽样方法,调查崇明县城桥镇40～70岁3 017名常住居民的脂肪肝患病情况,内容涉及问卷调查、体格检查、口服葡萄糖耐量试验、血脂等生化检测和肝脏实时B型超声(B超)检查。分析脂肪肝相关的危险因素。结果:3 017名居民完成调查,占崇明地区人口的80.15/万,其中男882名,女2 135名,平均年龄(55.6±8.0)岁。B超明确脂肪肝诊断共1 262例,占41.83%,经年龄和性别标化后,崇明地区脂肪肝的患病率为21.25%。标化后男、女患病率无统计学差异(24.53%比20.40%,P>0.05)。其中非酒精性脂肪性肝病患者1 120例,占脂肪肝总数的88.75%。单因素分析显示脂肪肝组的空腹血糖(FPG)、餐后2 h血糖(2hPG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、收缩压(SBP)、舒张压(DBP)、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、γ-谷氨酰转肽酶(GGT)均显著高于非脂肪肝组,高密度脂蛋白胆固醇(HDL-C)低于非脂肪肝组,差异均有统计学意义(P<0.000 1)。多元回归分析显示,年龄、2hPG、TG、LDL-C、SBP、ALT、GGT等指标与脂肪肝密切相关。结论:崇明地区脂肪肝患病率高,主要为非酒精性脂肪性肝病。年龄增长、血脂紊乱、高血压和糖尿病是脂肪肝患病的危险因素。
Objective To investigate the prevalence and risk factors of fatty liver among adult residents in Chongming District, Shanghai. Methods A cross-sectional survey with multiple stage stratified cluster and random sampling was performed. All residents aged from 40 to 70 were invited to participate the survey. Questionnaire, physical examination, serum lipid-profile, 75 g oral glucose tolerance test and uhrasonography of liver were undertaken. Analysis of data was performed through SPSS 13.0 for windows statistical package. Results A total of 3 017 residents participated the survey,which was 80.15/10 000 of the residents. Of the 3 017 residents surveyed, 882 were males and 2 135 were females. The mean age of the participants was （55.6＋8.0） years and ranged from 40-70 years. Fatty liver was detected by ultrasound examination in 1 262 participants （41.83%）. The age and gender adjusted prevalence of fatty liver was 21.25%. The standardized prevalence of fatty liver in males （24.53%） was similar to that in females （20.40%） （P〉0.05）. The prevalence of non-alcoholic fatty liver was 88.75%（1 120/1 262） in fatty liver . Mean age, fasting plasma glucose （FPG）, 2 h plasma glucose （2hPG）, systolic blood pressure （SBP）, diastolic blood pressure （DBP）, triglyceride （TG）,total cholesterol（TC）,low density lipoprotein cholesterol （LDL-C）,and alanine aminotransferase （ALT）, aspartate aminotransferase（AST）, gamma-glutamyltransferase （GGT） in fatty liver group was significantly higher than that in non-fatty liver group （all P〈0.000 1）; high density lipoprotein cholesterol （HDL-C） level was lower in fatty liver group than in non-fatty liver group （P〈0.000 1）. Logistic regression analysis demonstrated that the prevalence of fatty liver was positively correlated with age, postprandial glucose level,TG,LDL-C, SBP, ALT, GGT. Conclusions There was a high prevalence of fatty liver among adult residents in Chongming district, Shanghai, and non-alcoholic fatty liver was the major type. Aging, diabetes mellitus,hypertension and dyslipidemia were the risk factors of fatty liver.
出处
《内科理论与实践》
2012年第4期280-283,共4页
Journal of Internal Medicine Concepts & Practice
基金
国家自然科学基金青年项目(项目编号:30900699)
上海市科学技术委员会医学重点项目(项目编号:10411956600)
关键词
脂肪肝
患病率
流行病学
危险因素
Fatty liver
Prevalence
Epidemiological survey
Risk factors
