摘要
目的观察步长脑心通胶囊联合常规药物治疗对急性心肌梗死(AMI)患者经皮冠状动脉介入(PCI)术后氨基末端脑钠肽前体(NT-proBNP)的影响。方法将61例急诊行PCI的糖尿病AMI患者随机分成治疗组(n=31)和对照组(n=30)。治疗组给予步长脑心通胶囊、利尿剂、ACEI、地高辛口服及硝酸异山梨酯静滴,对照组仅给予利尿剂、ACEI、地高辛及硝酸异山梨酯静滴,治疗40 d,观察2组患者NT-proBNP的变化。结果治疗组NT-proBNP及症状、体征等指标的改善均优于对照组,差异有统计学意义(P<0.05)。结论使用步长脑心通胶囊加常规药物治疗AMI效果明显,值得在临床推广;NT-proBNP可用于监测AMI患者的病情变化及预后。
Objective To observe the influence of Buchang Naoxintong capsules therapy combined with Western medicine on NT-proBNP level of acute myocardial infarction （AMI） patients. Methods 61 diabetic patients with AMI who underwent routine emergency PCI were recruited and randomly divided into two groups：treatment group （n =31 ） and control group （n =30）. The treatment group was given oral Buchang Naoxintong capsule plus diuretics, ACE inhibitors, digoxin and intravenous infusion of isosorbide dinitmte, the cootrol group was only administrated with diuretics,ACE inhibitors,digoxin,and intravenous infusion of isosorbide dinitrate,the treatment course was 40 days. The changes of NT-proBNP in two groups were observed and compared. Results NT-proBNP, signs and symptoms and other indicators of im- provement in the treatment group were all better than those in the control group （P 〈 0.05 ）. Conclusion The use of Buchang Naoxintong capstde and the efficacy of conventional drugs in the treatment of acute myocardial infarction patients are obvious,and worthy of promotion in clinic practice. NT-proBNP has clinical significance for monitoring the condition changes and prognosis of patients with myocardial infarction, and it is convenient.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2012年第8期748-749,758,共3页
Journal of China Medical University
