摘要
目的通过磁共振氢质子波谱检查（1HMRs）研究慢性阻塞性肺疾病急性加重期（AEc0PD）患者大脑能量代谢物质的改变及与患者氧分压（PaO7）／-氧化碳分压（PaCO2）的关系。方法将13例AECOPD患者及年龄匹配的10例健康对照组行1HMRS检查，测定大脑顶-颞部和枕部的N-乙酰基天门冬氨酸（NAA）／肌酸复合物（Cr）、胆碱复合物（Cho）／Or、肌醇（MI）／Cr的比值，并行血气分析测定患者PaOz和PaCOz，研究大脑能量代谢物质的改变与患者PaOz和PaCOz是否具有相关性。结果AECOPD组顶-颞部及枕部NAA／Cr（1．32士0．12／1．48±0．12）均低于健康对照组（1．45±0．11／1．58±0．10）（P〈0．05，）MI／Cr（0．23±0．07／0．30±0．11）均低于健康对照组（0．40±0．14／0．46±0．12）（P〈O．01），AECOPD组顶-颞部及枕部Cho／Cr与健康对照组差异无统计学意义（P〉0．05）。顶-颞部及枕部NAA／Cr与Pa02呈正相关（r=0．46，0．44），顶-颞部及枕部MI／Or与Pa02呈正相关（r=0．63，0．50），顶-颞部MI／Cr与PaCO。呈负相关（r=0．47）。结论AECOPD患者可出现大脑代谢物质的改变，且和缺氧及二氧化碳潴留有一定的相关性。
Objective To study the cerebral energy metabolism changes of acute exacerbation of chronic obstructive pulmonary disease （AECOPD） through hydrogen magnetic resonance spectroscopy examination （1HMRS ） and its relationship with partial pressure of oxygen / carbon dioxide tension. Methods Totally 13 cases of AECOPD patients and 10 cases of age-matched healthy people underwent HMRS examination. The ratios of n-acetyl-aspartate（NAA）/creatine（Cr）, choline （Cho）/ Cr, myo-inositol（MI）/Cr of parieto-temporal and occipital areas of brain were detected. Blood gas analysis were also used to detect partial pressure of oxygen （PaO2） and carbon dioxide （PaCO2）. Results NAA / Cr of parieto -temporal and occipital areas of brain （1.32±0.12, 1. 48±0.12） were lower in AECOPD group than those in control group （1.45±0.11,1.58±0.10） （P〈 0.05）, MI/Cr （0.23±0.07, 0.30±0.11） were also decreased compared with control group （0.40±0.14, 0.46± 0.12） （P〈 0.01）, while Cho/Cr of parieto -temporal and occipital areas of brain between the AECOPD group and control group showed no significant difference （P〈0. 05）. NAA/Cr of parietotemporal and occipital areas of brain were positively correlated with Pa02 （r= 0. 46 and 0. 44）, and MI/Cr of these areas of brain were also positively related with PaO2 （r=0. 63 and 0. 50）, but MI / Cr of parieto tempora was negatively correlated with PaCO2 （r =-0. 472）. Conclusions Cerebral metabolite changes may occur in AECOPD patients, and this has relationship with hypoxia and carbon dioxide retention.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2012年第8期683-685,共3页
Chinese Journal of Geriatrics
基金
福建省科技计划重点项目（2009Y0038）
关键词
磁共振波谱学
肺疾病
慢性阻塞性
能量代谢
脑
Magnetic resonance spectroscopy Pulmonary disease, chronic obstructive Energy metabolism Brain
