多囊卵巢综合征患者血清IL-18的表达水平及其相关因素分析被引量：2

Analysis of Serum IL-18 Expression Level in Patients with Polycystic Ovary Syndrome and the Related Factors

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摘要目的探讨多囊卵巢综合征(PCOS)患者血清中IL-18的表达水平及其与各项性激素指标和代谢指标的相关性。方法选择30例PCOS患者为实验组,25例正常育龄期妇女为对照组;实验组在月经期第3天取空腹静脉血测定促黄体生成素(LH)、总睾酮(TT)、卵泡生成素(FSH)、空腹胰岛素(Insulin)及血糖(FBG)水平、胰岛素抵抗指数,采用酶联免疫吸附试验(ELISA)检测血清IL-18水平。结果两组间体重指数的差异有显著性(P<0.05);实验组Insulin、HOMA-IR和TT、LH/FSH明显高于对照组(P<0.05);实验组血浆IL-18水平明显高于对照组(P<0.05)。实验组患者IL-18水平与血清Insulin、HOMA-IR和TT、LH/FSH呈正相关,r值依次为0.43、0.38、0.42和0.40(P<0.05)。结论 PCOS患者血浆IL-18水平显著升高,且血清IL-18与Insulin和HOMA-IR呈显著正相关,与TT和LH/FSH水平也有显著正相关,提示IL-18在PCOS中具有重要意义。 Objective To explore the serum interleukin （IL）-18 expression level in patients with polycystic ovarian syndrome （PCOS）, and the correlation with various hormone index and metabolic indices. Methods 30 cases of PCOS patients were selected as experimental group, and 25 cases of women at normal reproductive age as control group; On the 3rd day of the menstrual period, serum was isolated from fasting venous blood to determine the serum luteinizing hormone （LH）, total testosterone （TT） and follicular erythropoietin （FSH） levels by the electrochemical luminescence immune method, at the same time testing fasting insulin （Insulin） and fasting blood sugar （FBG） levels, insulin resistance index （IR）; and serum IL-18 level was tested by ELISA. Results Body mass index （BMI） between the two groups showed significant difference （P〈0.05）; The Insulin, HOMA-IR and TT, LH/FSH in the experimental group were significantly higher than those in the control group （P 〈0.05）; plasma IL-18 level in the experimental group was obviously higher than that in the control group （P 〈0.05）. IL-18 level in the experimental group was positively associated with serum Insulin, HOMA-IR and TT, LH/FSH, correlation coefficient r value was 0.43, 0.38, 0.42 and 0.40 （P〈0.05）. Conclusions Plasma IL-18 level in PCOS patients significantly increases, and serum IL-18 has a significant positive correlation with Insulin, HOMA-IR, TT and LH/FS, which indicates the important significance of IL-18 in PCOS.

作者蔡春芳向贤宏俞奇栾峰王莹

机构地区南方医科大学附属中山市博爱医院妇产科中山大学附属第一医院介入放射科

出处《临床医学工程》 2012年第8期1261-1262,共2页 Clinical Medicine & Engineering

基金广东省自然科学基金(S2011040002502) 广东省医学科研基金(A2012825)资助

关键词多囊卵巢综合征白介素-18 胰岛素抵抗高雄激素血症 Polycystic ovary syndrome Interleukin （IL）-18 Insulin resistance High androgen hematic disease

分类号 R711.75 [医药卫生—妇产科学]

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参考文献6

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