摘要
(2S)-(二苯基羟甲基)-(4S)-苯氧基-四氢吡咯(10)由羟脯氨酸(6)经4步反应制得。用10催化6种前手性酮的不对称硼烷还原反应,其结果与(S)-二苯基脯氨醇催化的同一反应的结果进行了对比。
(2S) - (diphenylhydroxymethyl) - (4S) - phenoxy - pyrrolidine 10 was prepared from hydroxyproline 6 via a four - step sequence. Using 10 as the catalyst, six prochiral ketones were reduced enantioselectively with borane and the results were compared with those with 1,1- diphenylprolinol as catalys.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2000年第3期334-337,共4页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(批准号29572061)
江苏省教委自然科学基金
