摘要
目的检测BMP-2、BMP-4、BMP-7在前列腺癌骨转移灶中的表达,探讨其在前列腺癌成骨性转移中的作用。方法采用免疫组化EnVision法检测28例前列腺癌骨转移病例及17例良性前列腺增生(benign prostate hyperplasia,BPH)病例中BMP-2、BMP-4、BMP-7的表达并对其进行对比分析。结果 BMP-2在所有前列腺癌骨转移灶及BPH病例中均表达,二者中其阳性率及表达强度无明显差异(P>0.05)。BMP-4在前列腺癌骨转移灶及BPH中的阳性率无明显差异(P>0.05),但在前者中BMP-4的表达强度明显高于后者(P<0.05)。BMP-7在前列腺癌骨转移灶中的阳性率及表达强度均明显高于BPH(P<0.05)。在BPH的阳性表达病例中,BMP-2、BMP-4、BMP-7细胞质与细胞核同时阳性的表达率分别为13.3%、7.1%和11.1%,在前列腺癌骨转移灶的阳性表达病例中,BMP-2、BMP-4、BMP-7细胞质与细胞核的同时阳性的表达率均为100%,且细胞核的表达强度明显高于细胞质。结论 BMP-4、BMP-7在前列腺癌骨转移灶中高表达,提示其在前列腺癌的成骨性转移中可能起重要作用。
Purpose To analyze the expression of BMP-2, BMP-4, BMP-7 in prostate cancer with bone metastasis. Methods Immunohistochemical technique was used to detect the expression of BMP-2, BMP-4 and BMP-7 in the bone osteobastic metastastic lesions of prostate cancer and the benign prostate hyperplasia （BPH）. Results The expression of BMP-2 was detected in all samples and there was no difference between prostate cancer and BPH. The intensity of positivity of BMP-4 was higher in prostate cancer than that in BPH （ P 〈 0. 05）, but the difference of positive rate between these two groups showed no significance. The intensity of positivity and the positive rate of BMP-7 were higher in prostate cancer than that in BPH （ P 〈 0.05 ）. The positive rate of staining involving both cytoplasm and nuclear in BMP-2, BMP-4 and BMP-7-positive samples in BPH was respectively 13.3 %, 7.1% and 11.1%, respectively, but these in prostate cancer were all 100%, in which the intensity of nuclear staining was higher than that of cytoplasm. Conclusions The expression of BMP-4 and BMP-7 in the prostate cancer with bone osteobastic metastasis is higher than that in the BPH, which implies that they may play an important role in osteobastic metastasis of prostate cancer.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2012年第8期870-873,共4页
Chinese Journal of Clinical and Experimental Pathology
