摘要
目的 :研究大鼠急性脑损伤后脑组织单胺神经递质的变化。方法 :32只大鼠随机分成 4组 ,以落体致伤的方法造成右顶叶脑挫裂伤 ,测定伤后 2 ,6 ,2 4h脑挫裂伤灶周围脑含水量、Na+ Ca2 + 和单胺神经递质含量。结果 :脑损伤后随时间延长脑水肿程度逐渐增加 ,伤后 2 4h达高峰 ,脑组织Na+ 、Ca2 + 和单胺神经递质含量也随时间延长而增加。结论 :脑损伤后脑内儿茶酚胺类神经递质的过量释放 ,是外伤性脑水肿发展的重要因素之一。
Objective:To study the change of catecholamine (CA) following traumatic brain injury.Methods:32 adult SD rats were randomly divided into four groups(8 in each group) as sham nontraumatic group,2 h,6 h,24 h postinjury group.The right pareital cerebral lobe contusions were produced with a weight dropping method.Specimens around contusion were gathered.Concentrations of sodium,calciumion,CA and water content in the brain tissues were evaluated.Results:The result showed that the sodium,calcium concentration,contend of brain water and CA in brain tissue around contusion increased continuously after 2 horus postinjury.Conclusion:The experiment suggested that increases of sodium,calcium and CA following the acute traumatic brain injury is important in mechanisms of neuronal damage after brain injury.
关键词
颅及损伤
脑水肿
大鼠
单胺神经递质
brain injuries
brain edema
catecholamines
sodium
calcium
rats
