摘要
以硅橡胶囊为骨架,制成5氟尿嘧啶(5Fu)控释植入剂,观察对Walker 256移植性鼠肝癌的治疗效果。实验分对照组(A组)及治疗组(B组),每组Wistar大鼠12只。结果A、B组带瘤大鼠生存时间分别为(28.0±2.2)及(38.7±6.7)d(P<0.01),B组抑瘤率为96.3%。光镜下见B组癌细胞片状坏死,外周肝细胞排列整齐,肝小叶结构存在。初步临床应用结果表明,5-Fu控释剂对继发性肝癌治疗效果较好。
Fluorouracil controlled release implant,made of silastic elastomer,was investigated therapeautic effect on walker_256 carcinosarcoma in the liver of wistar rats.24 rats were divided into two group:control group(group A)and 5_Fu implant treated group(group B).The result revealed:group B had significantly long survival time compared with group A(P<0.01).A number of focal necrosises were found in cancer tissue by light microscope in group B.Clinical application of 5Fu controlled release implant is encouraging.
作者
贺银成
袁月英
陈纪伟
乔建国
史海安
He Yincheng;Yuan Yueying;Chen Jiwei(Depariment of General Surgery,Secornd Affiliated Hospital,Hubei Medical University,Wuhan 430071,China)
关键词
氟尿嘧啶
控释系统
肝肿瘤
大鼠
fluorouracil
drug delivery system
liver
neoplasms/TH
