摘要
目的：观察化疗药物顺铂和氟脲嘧啶对人小肠动力的影响。方法：应用液体灌注胃肠动力测压系统动态测定了１８例化疗患者 ４８ ｈ空腹小肠动力的变化并记录呕吐情况。结果： １８例患者化疗后小肠动力明显加快，表现为移行运动复合波（ＭＭＣ）数目从对照组的８．８３±２．３３个增多至１３．１１±３．５３个，周期从１７４ ｍｉｎ±４６ ｍｉｎ缩短至１２０ ｍｉｎ±４２ ｍｉｎ，移行速度从０．１１２ ｃｍ·ｓｅｅ－１±０．０２５ｃｍ·ｓｅｃ－１加快至０．１６２ｃｍ·ｓｅｃ－１±０．０４５ｃｍ·ｓｅｃ－１，ＭＭＣⅢ相收缩波数也明显增多，但ＭＭＣⅢ相收缩波幅值却不增高。其中９例患者化疗后发生呕吐。结论：化疗药物可引起呕吐并同时加快小肠动力，但两者之间无因果关系。
Objective: To evaluate the effects of cisplatin and fluorouracil in human interdigestive bowel motility. Methods: 18 patients were monitored as to their intestinal motility by using a liquid perfusion gastrointestinal motility monitoring system for 48 hours. The first 24 hours was taken for the control, the second 24 hours was a chemotherapeutic period. In this period, cisplatin (dose 40 mg) and fluorouracil (dose 500 mg) were injected, and emesis of each patient was recorded. Results: The results showed that chemotherapeutic drugs resulted in emesis (9/18) and increased intestinal motility, which manifested as increased MMC frequency from 8. 83 ± 2. 33 in the control period to 13. 11 ± 3. 53 in the therapeutic period, shortened MMC cycle from 174 min ± 46 min to 120 min ± 42 min, accelerated velocity of MMC propagation from 0. 112 cm .sec-1 ± 0. 025 cm· sec -1 to 0. 162 cm· sec-1 ± 0. 045 cm· sec- l, and increased MMC Ⅲ contractile fronts, but the amplitude values of MMC Ⅲ contractile fronts was not increased. Conclusion: This study showed that chemotherfapeutic drugs caused emesis and increased intestinal motility in patients, but whether or not the causal relationships existed between them would need further study.
