NT-proBNP在不同NYHA分级中的意义被引量：14

Significance of NT-proBNP in Patients of Different NYHA Classes

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摘要目的探讨血浆NT-proBNP浓度变化在慢性心力衰竭患者中的意义。方法选择慢性心力衰竭患者65例作为试验组,NYHA分级分为Ⅱ～Ⅳ级,正常对照组21例,测定NT-proBNP血浆浓度。结果各组间NT-proBNP比较差异有统计学意义(P<0.01),NT-proBNP与NYHA分级呈正相关(r=0.509,P<0.01),抗心力衰竭治疗7 d后,与入院时相比各心力衰竭组NT-proBNP明显下降(P<0.01)。结论 NT-proBNP对慢性心力衰竭的诊断、严重程度的判断、疗效判定是一项快速、简便的指标,值得广泛应用于临床心力衰竭患者。 Objective To study the significance of plasma NT-proBNP changes in patients with chronic heart failure. Methods 65 cases with chronic heart failure were selected and divided them into Ⅱ -Ⅳ class by NYHA class,21 cases without heart failure were included as the control group. Their NT-proBNP plasma concentrtion ,vere tested. Results The differences of NT-proBNP in different group were significant（ P 〈0. 01 ） ; NT-proBNP showed positive correlation with NYHA class （ r = 0. 509, P 〈 0.01 ）. After 7 days＇ anti- heart failure therapy, compared to when admitted to the hospital the NT-proBNP in each NYHA class decreased significantly（ P 〈 0.01 ）. Conclusion Monitoring NT-proBNP is a quick and easy index for accurate diagnosis,judging the severity and determining the efficacy of chronic heart failure ,which should be widely used in clinical heart failure patients.

作者王玲孙晶

机构地区内蒙古自治区人民医院心血管内科

出处《医学综述》 2012年第14期2274-2276,共3页 Medical Recapitulate

关键词氮端前体脑钠肽心力衰竭 NYHA分级 NT-proBNP Heart failure NYHA class

分类号 R541.6 [医药卫生—心血管疾病]

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