摘要
雌激素受体α(ERα)属于类固醇激素受体超家族,是细胞核中需要配体激活的转录因子,对细胞和组织的增殖、分化和发育有重要的调节作用。c-Myc是ERα目的基因,属于Myc基因家族,是一种核蛋白类的原癌基因。ERα调控着c-Myc的表达,而c-Myc的表达变化也影响着ERα的功能发挥,彼此之间存在关联。它们在哺乳动物植入前胚中呈阶段特异性表达,在植入前胚发育中发挥一定作用。
Estrogen receptor-a（ERct）, member of the steroid hormone receptor gene superfamily that acts as ligand-inducible transcription factor and plays an important role in regulating the proliferation, differentiation and development of cells and tissues, c-Myc, the ERa target gene,which belongs to Myc gene family, is a kind of nucleoprotein class protooncogene. ERa regulates the expression of c-Myc, at the same time, the expression of c-Myc changing also affects the function of ERa, they are associated with each other. ERa and c-Myc expression are stage-specific in preimplantation embryos, suggesting that their functions might be involved in the development of mammalian preimplantation embryos.
出处
《医学综述》
2012年第14期2153-2155,共3页
Medical Recapitulate
基金
国家自然科学基金(81170624)
