摘要
研究吉法酯对DMF和乙醇联合致胃黏膜损伤的保护作用。大鼠随机分为3组。各组提前药物灌胃,然后用DMF和乙醇致胃损伤,测定胃黏膜溃疡指数、胃黏膜血流、胃黏膜氨基己糖含量,并观察组织学变化。预防组与损伤组比较,胃黏膜损伤指数明显下降,胃黏膜血流明显增加,胃黏膜氨基己糖含量亦明显增加。吉法酯对DMF和乙醇联合致大鼠急性胃黏膜损伤具有预防保护作用。
To determine the protective effects of gefarnate on gastric mucosal lesions induced by Dimethylformamide （DMF） and alcohol in rats, 30 healthy male Wistar rats were randomly and equally divided into four groups： normal group, injury group, gefarnate protective group （400mg/kg）. Gastric mucosal lesions were induced by DMF and alcohol. Rats of protec- tive groups were pretreated with drugs that mentioned above respectively before induction of gastric mucosal lesions. Gas- tric mucosal blood flow and content of hexosamine were measured and the histological changes were evaluated under micro- scope. Compared with injury group, ulcer index of protective groups were significantly decreased （P〈0. 001}, gastric mu- cosal blood flow and content of hexosamine were significantly increased （P〈0. 001）. Inflammation and injury in histologi- cal slide of protective groups were slight. Gefarnate can reduce gastric mucosal lesions induced by DMF and alcohol in rats.
出处
《医学与哲学（B）》
2012年第7期56-58,共3页
Medicine & Philosophy(B)
基金
辽宁省教育厅课题
项目编号:L2010296
关键词
吉法酯
二甲基甲酰胺
乙醇
胃黏膜
预防保护
gefarnate, dimethylformamide, alcohol, gastric mucosal, protection
