摘要
目的 :探讨空腹胃液、胃粘膜组织总胆汁酸 (TAB)的含量对胆汁返流性胃炎的诊断价值。方法 :对 47例胆汁返流性胃炎 (RG)组 ,15例消化性溃疡 (PU)组 ,2 0例慢性浅表性胃炎 (CSG)组及 12例正常对照组在胃镜检查的同时 ,抽取胃液 ,钳取胃粘膜组织作 TBA含量测定。胃粘膜组织同时作 HP及病理组织学检查。结果 :胆汁返流性胃炎组胃液及胃粘膜组织 TBA含量分别为 (315 .85 5 0± 35 .946 8)μm ol/ L ;(0 .2 10 7± 0 .0 810 )μmol/ g。明显高于 PU、 CSG及正常对照组 (P <0 .0 0 1)。胃粘膜组织 TBA含量与胃液 TBA含量呈明显正相关 ,rs=0 .82 8,P <0 .0 0 1。胃粘膜的炎症程度也随 TBA含量的增加而加重。χ2 =15 .6 37,P <0 .0 0 5。随着 TBA含量的增加 ,HP的检出率下降 ,χ2 =9.42 ,P <0 .0 1。结论 :胃液、胃粘膜组织 TBA含量对胆汁返流性胃炎有诊断价值。而胃粘膜组织 TBA含量更有价值。
Objective:Total bile acid (TBA) in endoscopic biopsy specimens of gastric mucosa and fasting gastric juice was examined to elucidate its genesis of reflux bile gastritis (RG).Mothods:TBA concentration was measured and the samples of gastric tissues ware also examinated by pathologist including 47 reflux gastritis 15 peptic alcer(PU) 20 clonic superficial gastritis (CSA) and 12 control.Results:TBA concentration in tissue and juice was significantly higher than that in PU;CSG;Control.RG:(315.855±35.946 8)μmol/L,(0.210 7±0.08)μmol/g;PU:(27.82±5.225)μmol/L,(0.035 3±0.003 2)μmol/g;CSG:(24.49±2.906 8)μmol/L,(0.034 6±0.006)μmol/g;Control:(22.283 3±5.294 4)μmol/L,(0.033±0.008 5)μmol/g.(P<0.001).Not only damage degree of the gastric nucosa increased in paralled with the level of TBA (P<0.005),but also the tissue and fasting gastric juice (r s =0.828;P<0.001).Helicobacter pylori infaction rate decreased in the patients with higer level of TBA (P<0.01).Conclusion:The detection of gastric mucosa TBA measurement may be helpful for diagnosis of reflux bile gastritis.
出处
《广西医科大学学报》
CAS
2000年第1期36-38,共3页
Journal of Guangxi Medical University
