摘要
目的 :为观察中药葛根素与地尔硫及 SOD对心肌缺血再灌注损害的保护作用。方法 :将 45只小型猪造成在体心肌缺血再灌注模型 ,分为 5组 ,分别于再灌注前经静脉注射生理盐水、 SOD、地尔硫 (DTZ) ,DTZ+SOD和葛根素。结果 :1心梗范围占左室质量的百分数 ,用药各组与对照组比较 ,均有显著性缩小 ,P <0 .0 1;DTZ+SOD组与 SOD组比较 ,亦有显著缩小 ,P<0 .0 5 ;2心肌钙离子含量 :SOD组与对照组比较有降低 ,但无显著性差异 ,而 DTZ组、SOD+DTZ组及葛根素组与对照组比较均有显著性的降低 ,P <0 .0 1;3用药组均有降低灌注后 CK- MB的作用。 DTZ组、 SOD+DTZ组及葛根素组灌注后的 CK- MB与对照组比较均有显著性差异 ,P <0 .0 1,与 SOD组比较 ,DTZ组、SOD+DTZ组及葛根素组均有显著性降低 ,P <0 .0 1。结论 :SOD、 DTZ、葛根素对缺血再灌注心肌有明确的保护作用 ,但 DTZ、葛根素效果优于 SOD,葛根素的效果与 DTZ近似 ,合用 SOD+DTZ较应用其中单一药物效果更好。
Objective:To study the protective effect of puerarin,diltiazem and SOD on reperfusion injury of ischemic myocardium Methods:Forty five piglets were modelled as the reperfusion injury of ischemic myocardium The piglet's models were divided into 5 groups,and were intravenously injected with physiological saline (as controls),SOD,DTZ,DTZ+SOD and puerarin respectively Results:①Myocardiac infarction size accounted for the percentage of weight of the left ventricle:In comparison between each drug therapeutic group and control group,the former were markedly reduced,P<0 01 DTZ+SOD compared with SOD,the percentage of combined drugs therapeutic group was also markedly reduced,P<0 05;②Calcium ion content in myocardium:SOD group is reduced,but there was no significant difference,while DTZ group and SOD+DTZ group and puerarin group compared with control group were markedly reduced,P<0 01;③The drug therapeutic groups all had the action of dropping CK MB after reperfusion DTZ,SOD+DTZ and puerarin group compared with control group,there were significant difference,P<0 01 Comparing with SOD,the DTZ and SOD+DTZ as well as puerarin group were markedly reduced,P<0 01 Conclusion: There is markedly protective effect of SOD,DTZ and puerarin on reperfusion injury of ischemic myocardium;but the efficacy of DTZ and puerarin was better than SOD The efficacy of puerarin was similar to DTZ The efficacy of combined SOD and DTZ was better than just SOD or DTZ
出处
《广西医科大学学报》
CAS
2000年第1期33-35,共3页
Journal of Guangxi Medical University
