摘要
目的 了解NO在先天性心脏病中的作用及临床意义。方法 用Geriss硝酸盐还原法测定几种先天性心脏病患儿和正常对照组的NO水平。结果 与对照组相比 ,室间隔缺损 (VSD)患儿、房间隔缺损 (ASD)患儿、动脉导管未闭 (PDA)患儿NO水平增高且有显著差异 (P <0 0 5 ) ;法洛氏四联症 (F4)患儿NO水平降低但无显著差异 (P >0 0 5 )。其中先天性心脏病伴肺动脉高压者NO水平高于对照组且有显著差异 (P <0 0 5 ) ;而先天性心脏病无肺动脉高压者与对照组相比无显著差异 (P >0 0 5 )。结论 NO在先天性心脏病中起一定的作用 。
Objective In order to find out the function of NO in congenital heart disease we observed the level of nitric oxide (NO) in several kinds of congenital heart disease.Methods The effects of NO in several kinds of congenital heart disease were examined by Geriss nitrate reduction method.Results Compared with healthy group,the level of NO in VSD Children、ASD children and PDA children were significantly increased(P<0.05);the level of NO in F4 children were not significantly(P>0.05);the congenital heart disease children with pulmonary hypertension(PH) were significantly increased(P<0.05) and the congenital heart disease children without PH were not significantly(P>0.05).Conclusion These results suggest that NO has much effect in congenital heart disease and NO play an important role in the congenital heart disease children with PH.
出处
《中国全科医学》
CAS
CSCD
2000年第3期188-189,共2页
Chinese General Practice
关键词
先天性心脏病
一氧化氮
肺动脉高压
儿童
Congenital heart disease Nitric oxide Pulmonary hypertension
