摘要
目的 了解针灸治疗类风湿关节炎 (RA)的疗效 ,并探讨其消炎镇痛作用机制。方法 将 45例RA患者随机配对以 1∶2分为针灸组 (30例 )和消炎痛组 (15例 )。观察其疗效并测定部分患者治疗前后超氧化歧化酶 (SOD)、脂质过氧化物酶 (LPO)的改变和亮脑啡肽 (LEK)的变化。结果 针灸组与消炎痛组治疗RA疗效相似 (P >0 0 5 ) ,治疗前后的关节肿胀指数、关节压痛指数、晨僵、握力、红细胞沉降率 (ESR)、类风湿因子 (RF)均下降。治疗前后SOD和LPO降低 ,而LEK明显升高。结论 针灸治疗RA具有消炎镇痛作用 ,其机制可能与亮脑啡肽升高 ,调节自由基代谢有关 ,同时发现针灸治疗能使ESR明显下降 ,RF滴度下降 。
Objective To observe the effect of acupuncture on patients with rheumatoid arthritis and study the mechanism of antiinflammation and analgesia of acupuncture in RA.Methods Patients with RA were divided into two groups:treated with acupuncture (30 case),and with indomethacin.The curative effect was evaluated at 4th week after the treatment,and LPO,LEK and the activity of SOD in plasma were detected respectively at the begin and end of treatment in part of patients in acupuncture group.Results The total effective rate of acupuncture group was 83 3%,There was no significant difference between acupuncture and indomethacin groups ( P <0 01).The number of painful joint,number of swelled joint,duration time of morning stiffness and grip strength showed significant improvement.ESR,titer of RF,activity of SOD and level of LPO decreased and the level of LEK increased obviously after treatment with acupuncture in RA patients.Conclusion There is some effect of acupuncture on early RA and the mechanism of antiinflammation and analgesia of acupuncture may be related to LEK,SOD and LPO.
关键词
类风湿性关节炎
针灸疗法
消炎镇痛
Acupuncture
Arthritis,rheumatoid
Enkephalin,leucine
Superoxide dismutase
Lipid peroxides
