摘要
目的观察甘油果糖联合甘露醇序贯治疗脑水肿的临床疗效,探讨其对肾功能的影响。方法将2010年1月至2011年12月来我科治疗的52例脑水肿患者按所接受的不同治疗方法分为观察组和对照组,其中观察组28例,给予甘油果糖联合甘露醇治疗,对照组24例,给予甘露醇治疗。观察两组临床疗效和对肾功能的影响情况。结果两组治疗脑水肿的效果相似,差异无统计学意义(P>0.05),但是观察组在使用甘油果糖联合甘露醇治疗两周后能显著减对轻肾功能的损害,维持电解质平衡,改善脑组织周围水肿以及降低神经功能缺损评分,差异均有统计学意义(P<0.05)。结论甘油果糖联合甘露醇序贯治疗脑水肿可以明显减轻对肾功能的损害等,不良反应小,值得推广应用。
Objective To observe the therapeutic effect of glycerin and fructose combined with mannitol in the treatment of cerebral edema, and to investigate the influence of the treatment on renal function. Methods Fif- ty-two patients of cerebral edema in our department from Jan. 2010 to Dec. 2011 were randomly divided into two groups. The observation group （28 cases） was treated by glycerin and fructose combined with mannitol, and the con- trol group （24 cases） was treated by marmitol. The clinical effects and the change of the renal function were observed. Results The clinical effect of the observation group and the control group was similar, and the difference was not sta- tistically significant （P〉0.05）. Two weeks after treatment, glycerin and fructose combined with mannitol can signifi- cantly reduce renal damage, balance electrolyte, reduce the volume of cerebral edema and score of neural function de- feet （P〈0.05）. Conclusion The effect of combined treatment is better than single marmital for treating cerebral edema, which is worthy to be promoted.
出处
《海南医学》
CAS
2012年第16期28-30,共3页
Hainan Medical Journal
关键词
脑水肿
甘油果糖
甘露醇
不良反应
Cerebral edema
Glycerin and fructose
Marmitol
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