摘要
目的观察红麻茶对大鼠高糖高脂饲料所致非酒精性脂肪肝(NAFLD)的降脂保肝作用。方法将40只SD大鼠随机分为5组:对照组、模型组、红麻茶低剂量组、红麻茶高剂量组、复方蛋氨酸胆碱片组,除对照组喂基础饲料外,其余各组喂高糖高脂饲料;给药组给予不同剂量的红麻茶(2.42、7.26g·kg-1·d-1)以及复方蛋氨酸胆碱片(1.2g·kg-1·d-1)进行灌胃给药,连续6周,观察大鼠肝脏病理变化并检测各组血清三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、丙氨酸氨基转移酶(ALT)、天门冬酸氨基转移酶(AST)和肝组织TC、TG、超氧化物歧化酶(SOD)、谷胱甘肽(GSH)及丙二醛(MDA)的水平。结果红麻茶高剂量能明显降低肝指数、血清ALT、AST,降低血清与肝TC、TG、LDL-C及肝组织中的MDA,升高GSH及SOD,且肝细胞脂肪变性和水样变性程度明显减轻。结论红麻茶具有明显的降脂保肝作用,且优于复方蛋氨酸胆碱片。能显著降低体内血脂和肝内脂肪,降低转氨酶水平,并且提高机体抗氧化活力,明显抑制脂质过氧化及清除体内自由基。
Objective To determine the lipid-lowering and liver-protecting effect of Hongmacha against nonalcoholic fatty liver disease（NAFLD） in rats.Methods Fifty male rats were randomly divided into 5 groups： a normal group,a model group,a high-dose group,a low-dose group and a compound methionine and choline bitartrate tablet group.All of the groups were fed with high glucose and fatty diet except the normal group.The rats were intragastrically administered Hongmacha（2.42,7.26 g·kg-1·d-1） and compound methionine and choline bitartrate tablets（1.2 g·kg-1·d-1） for 6 weeks.Levels of TG,TC,LDL-C,ALT,AST in the serum,and TC,TG,MDA,GSH and SOD in the hepatic tissue were detected,and pathological changes of the liver were observed under light microscope after 6 weeks.Results Compared with the model group,the Hongmacha high-dose group obviously reduced the liver index,ALT and AST,the serum levels of TC,TG,LDL-C,and TC,TG,MDA in the hepatic tissue were significantly lowered,and the levels of hepatic SOD and GSH were significantly increased.Steatosis and hydropic degeneration were reduced significantly.Conclusion Hongmacha is superior to compound methionine and choline bitartrate tablets in protecting liver and reducing the lipid in hyperlipidemic fatty livers.Blood lipid,liver lipid and enzyme level are lowered remarkably by Hongmacha,which can aslo effectively protect the liver by improving the hepatic anti-oxidative capability,inhibiting lipid peroxidation and eliminating oxide free radicale of the body.
出处
《中南药学》
CAS
2012年第7期522-525,共4页
Central South Pharmacy
关键词
红麻茶
非酒精性脂肪肝病
降脂保肝
Hongmacha
nonalcoholic fatty liver disease
lipid-lowering and liver-protecting
