摘要
目的:研究转化生长因子-β1-509(transforming growth factor-β1-509,TGF-β1-509)基因多态性各等位基因及基因型在绝经后女性2型糖尿病(type 2diabetes mellitus,T2DM)患者中的分布频率,探讨其基因型及分布频率与骨质疏松症(osteoporosis,OP)的相关性。方法:上海地区汉族绝经女性患者共282例,其中OP患者105例(OP组),T2DM患者骨量正常患者90例(T2DM组),T2DM并发OP患者87例(T2DM并发OP组);另取健康绝经女性82例作为对照(对照组)。检测TGF-β1-509基因多态性、第2～4腰椎(L2-4)骨密度(bone mineral density,BMD),同时检测血浆糖化血红蛋白A1c(hemoglobin A1c,HbA1c)。比较各临床指标与TGF-β1-509基因型的相关性。结果:OP组、T2DM组、T2DM并发OP组和对照组TGF-β1-509相比,等位基因型C、T的分布均无显著差异。合并OP组(OP组+T2DM并发OP组)和非OP组(T2DM组+对照组)TGF-β1-509等位基因型C、T的分布频率比较有显著差异(P=0.015)。CC基因型、CT基因型、TT基因型比较,其HbA1c差异无统计学意义。结论:TGF-β1-509等位基因型T可能是OP的易感基因,T2DM患者TGF-β1-509基因型与HbA1c无相关性。
Objective： To explore the distribution of polymorphism of transforming growth factor-betal （TGF-β1） gene in shanghai post-menopausal women with type 2 diabetes mellitus （T2DM）, and to investigate the relationship between TGF-β1 genotypes and osteoporosis（OP）. Methods： A total of 282 unrelated post-menopausal women of Han nationality in Shanghai re- gion were recruited and divided into three groups. They were OP group （Group OP n = 105）, T2 DM group （Group T2 DM, n = 90） and T2DM ＋ OP group （Group T2DM ＋ OP n = 87）. Another 82 healthy post-menopausal women of Han nationality in Shanghai region were also enrolled （Group control n = 82）. TGF-β1-509 gene polymorphism as well as hemoglobin Ale （HbAlc） were detected, and the bone mineral density （BMD） in lumbar spine （L2-4） was measured. Results： There was no significant difference in the distribution of allele T and C among Group OP, Group T2DM and Group T2DM ＋ OP. The allele frequency distribution on C and T in subjects with OP （Group OP, Group T2DM ＋ OP） and without OP （Group T2DM, Group control） showed significant difference （P-0. 015）. There were no significant differences in the levels of HbAlc among the different genotypes of CC, CT and TT. Conclusions： TGF-131-509 T allele may be the susceptible gene to OP. The TGF-β1- 509 genotypes of T2DM patients of had no correlation with HbAlc.
出处
《中国临床医学》
2012年第3期215-217,共3页
Chinese Journal of Clinical Medicine
基金
国家自然科学基金(编号:30872726)
