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MEF2基因家族的研究进展 被引量：19

The Research Progress of MEF2 Gene Family
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摘要 肌细胞增强因子2(MEF2)属于转录调节因子MADS-Box家族,是一种特定的转录因子。在脊椎动物中,MEF2基因家族由4个基因组成,包括MEF2A、MEF2B、MEF2C和MEF2D,它们在肌肉生成、神经系统发育和分化、肝纤维化方面均有重要作用。本文从MEF2基因的结构、组织分布和生物学功能等方面,对该基因家族的研究进展进行了综述。 Myocyte enhancer factor 2 （MEF2） is a specific transcription factor of MADS-Box family. It is a single gene in Drosophila and C. Elegans, but in vertebrates, MEF2 gene are multi-gene family, including MEF2A, MEF2B, MEF2C and MEF2D. They took an important role in myogenesis, development and differentiation of nervous system and liver fibrosis.The structure, tissue distribution and biological function of MEF2 genes were summarized in this review paper.
作者 程波 李利 王林杰 张红平
机构地区 四川农业大学动物遗传育种研究所
出处 《中国畜牧杂志》 CAS 北大核心 2012年第15期70-74,共5页 Chinese Journal of Animal Science
基金 四川省科技支撑计划(2011NZ0003 2011NZ0017)
关键词 肌细胞增强因子2 生物学功能 综述 myocyte enhancer factor 2 biological function a review
分类号 S813.1 [农业科学—畜牧学]
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参考文献34

  • 1Brand N J. Myocyte enhancer factor 2 (MEF2) [J]. Int J Biochem Cell Biol, 1997, 29(12): 1467-1470.
  • 2Black B L, Olson E N. Transcriptional control of muscle develop- ment by myocyte enhancer factor-2 (MEF2) proteins [J]. Annu Rev Cell Dev Biol, 1998, 14: 167-196.
  • 3Martin J F, Miano J M, Hustad C M, et ol. A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splic- ing[J]. Mol Cell Biol, 1994, 14(3): 1647-1656.
  • 4Hobson G R M, Krahe R A, Garcia E M, et al. Regional chro- mosomal assignments for four members of the MADS domain tran- scription enhancer factor 2 (MEF2) gene family to human chro- mosomes 15q26, 19q12, 5q14, and lq12-q23[J]. Genomics, 1995, 29(3): 704-711.
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二级参考文献69

  • 1Breitbart RE, Liang CS, Smoot LB, et al. A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage. Development, 1993, 118 (4): 1095-1106.
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  • 5Naya FJ, Black BL, Wu H, et al. Mitochondrial deficiency and cardiac sudden death in mice lacking the MEF2A transcription factor. Nat Med, 2002, 8 (11): 1303 - 1309.
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共引文献31

同被引文献217

引证文献19

二级引证文献39

中国畜牧杂志
2012年 第15期

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