摘要
目的 探讨有关羊水Ⅲ°污染和胎膜早破 >2 4小时的新生儿生后预防性应用抗生素与感染发病的关系。方法1996年 3月～ 1998年 4月本院出生的 2 47例羊水Ⅲ°污染和 117例胎膜早破 >2 4小时的新生儿分别设为Ⅰ组和Ⅱ组 ,生后不论有无感染均肌注头孢氨噻肟 10 0mg/ (kg·d)共 5天 ,用药前做腔道 (眼、鼻、耳、咽 )分泌物培养 ,部分新生儿加做血培养。同期出生无以上二种情况的新生儿 2 5 13例作为对照组。结果 对照组发生感染 45例 ,发病率 1.79%。Ⅰ组发生感染 14例 ,发病率 5 .66% ,明显高于对照组 ( χ2 =16.16,P <0 .0 1)。Ⅱ组发生感染 1例 ,发病率 0 .85 % ,与对照组比较无显著差异 ( χ2 =0 .5 7,P >0 .0 5 )。结论 胎膜早破疑有宫内感染的新生儿生后预防性用抗生素可降低感染发病率 ,而羊水Ⅲ°污染有胎窘、产时窒息的新生儿生后尽管应用抗生素仍不能降低感染的发病率 。
objective To discuss the relationship between the prophylactic use of antibiotics and infectious diseases in the newborn babies with Ⅲ° polluted amniotic fluid or with break of fetal membrane 24 hours earlier than usual.Method The babies born from March, 1996 to April, 1998 in our hospital were divided into three groups.Group Ⅰ(247 cases with Ⅲ° polluted amniotic fluid) and group Ⅱ(117 cases with break of fetal membrane 24 hours earlier than usual) were all injected intramusclarly with ciafoian 100mg/kg daily for five days.Secretion of their eyes,noses,ears,throats and blood of some babies were cultivated before injection.2513 normal babies born during the same time served as control group.Results There are 45 infected cases in control group(1.79%),14 cases infected in Group Ⅰ,the incidence rate(5.66%) was obviously higher than that of the control group(χ 2=16.16, P <0.01).Only one case was infected in Group Ⅱ,the incidence rate(0.85%) was not significantly different from that of the control group(χ 2=0.57, P >0.05).Conclusions The babies with break of fetal membrane earlier than usual and who are doubted to get infection from the womb can be injected with antibiotics to decrease the incidence rate of infection.However,the babies with Ⅲ°polluted amnitotic fluid,accompanied with fetus distress or birth suffocation still keep a higher incidence of infection,though they are offered antibiotics after birth.So it is very important to prevent fetus distress and birth suffocation of babies.
出处
《现代诊断与治疗》
CAS
2000年第2期79-80,共2页
Modern Diagnosis and Treatment
关键词
新生儿感染
羊水污染
胎膜早破
预防性抗生素
Newborn baby
Ⅲ° polluted amniotic fluid
Early break of fetal membrane
Antibiotics
