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新型肿瘤增殖指标―血清胸苷激酶1的临床应用 被引量：9

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摘要 胸苷激酶（thymidinekinase，简称TK）是嘧啶代谢循环中的关键酶之一，它能够催化脱氧胸苷（deoxythymidine，dTdR）转变为脱氧胸苷酸（deoxythymidylicmonophosphate，dTMP）。早在60年代就有文献报导指出，DNA合成之前，TdR摄入细胞并转化为TMP必须有磷酸化激酶催化。
作者 张国庆 焦顺昌
机构地区 中国人民解放军总医院肿瘤内科
出处 《现代肿瘤医学》 CAS 2012年第8期1743-1745,共3页 Journal of Modern Oncology
基金 国家科技部支撑计划基金资助项目(编号:2009BAI86B05)
关键词 肿瘤 增殖指标 血清胸苷激酶
分类号 R730.231.1 [医药卫生—肿瘤]
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参考文献17

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  • 3He Q ,Zou L, Zbang PA, et al. The clinical significance of thymidine kinase 1 measurement in serum of breast cancer patients using anti - TK1 antibody [ J]. Int J Biol Markers, 2000, 15 : 139 - 146.
  • 4He Q, Forrlander T, Johansson H, ct al. Thymidine kinase 1 inserum predicts increased risk of distant or loco - regional recur- rence following surgery in patients with early breast cancer [ J l- Anticaucer Res, 2006, 26 : 4753 - 4759.
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  • 6Xu XH, Zhang YM, Shu XH, et al. Serological thymidine kinase 1 reflects progression of pre - malignant and malignant tumours during therapy [J]. Mol Med Rep,2008,1:705 -712.
  • 7Chen ZH, Zhou H Tian NB, et al. Serological thymidine kinase 1 ( S - TK1 ) indicates an elevated risk for development of malignant tumours [ J]. Anticancer Res, 2008,6:3897 - 3907.
  • 8张兴华,杨金荣,付筱英,秦蕾,刘海燕,汪海霞,云霞,宋波,张旻,Ellen He,Sven Skog.血清胸苷激酶1对癌前疾病的癌变风险筛查的意义[J].中华健康管理学杂志,2010,4(1):35-38. 被引量：10
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  • 10Li ZS, Wang YH, He J, et al. Serological thymidine kinase 1 is a prognostic factor in esophagus, cardial and lung carcinomas [J]. EurJCancerPrev, 2010, 19(4): 313 -318.

共引文献9

同被引文献92

  • 1黄玉阳,赵春玲,张冰璐,房怡菲,代丽萍,欧阳松云.FUT7甲基化联合CT影像特征预测肺腺癌发生风险的列线图模型[J].中国呼吸与危重监护杂志,2024,23(2):95-104. 被引量：3
  • 2李莎,惠开元,孙文,胡晨曦,王梅,蒋晓东.硫氧还蛋白还原酶在肺癌临床检测中应用[J].临床军医杂志,2020(12):1415-1417. 被引量：7
  • 3顾光大.血清胃蛋白酶原、胸苷激酶联合检测对胃癌的诊断意义[J].实用医学杂志,2009,25(5):715-717. 被引量：14
  • 4曾智杰,欧阳文婷,孙艳虹,蔡小华.胸苷激酶1在白血病患者化疗过程中的临床意义探讨[J].分子诊断与治疗杂志,2009,1(1):28-30. 被引量：12
  • 5Mao Y,Wu J,Skog S,et al. Expression of cell proliferating genes inpatients with non - small cell lung cancer by immunohistochemis -try and cDNA profiling [J] . Oncol Rep ,2005,13 (5) :837 - 846.
  • 6He Q,Fornander T, Johansson H,et al. Thymidine kinase in serumpredicts risk of distant or locoregional recurrence following surgeryin patients with early breast cancer [ J ]. Anticancer Res, 2006,26(6c) :4753 - 4759.
  • 7Fabio Gaspairi, Naining Wang,Sven Skog, et al. Thymidine kinase1 expression defines an activated Gj; state of the cell cycle as re-vealed with site - specific antibodies and array scan assays[ J] . EurJCell Biol,2009,88(12):779.
  • 8Li X,Lei DS,Wang XQ,et al. Serum thymidine kinase 1 is a prog-nostic and monitoring factor in patients with non - small cell lungcancer[J] . Oncol Rep,2005 ,13(1) :145 - 149.
  • 9Zhang J, Jia Q, Zou S, et al. Thymidinekinase 1 ; a proliferationmarker for determining prognosis and monitoring the surgical out-come of primary bladder carcinoma patients [ J ] . Oncol Rep,2006,15(2) :455 -461.
  • 10He E,Xu XH,GuanH,Chen Y,et al. Thymidine kinase 1 is a po- tential marker for prognos is and monitoring the response to treat- ment of patients with b reast,lung, and esophageal cancer and non Hodgkins lymphoma [ J ]. Nucleoside, Nucleoside and Nucleic Acid,2010:29(46) :352-358.

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现代肿瘤医学
2012年 第8期

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