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脂肪甘油三酯水解酶的研究进展 被引量：4

Progress in Studies on the Adipose Triglyceride Lipase
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摘要 胰岛素抵抗等代谢疾病的发生与脂代谢紊乱密切相关。细胞中的脂肪主要储存在一个以中性脂为核的细胞器——脂滴(lipid droplet,LD)中。脂肪甘油三酯水解酶(adiposetriglyceride lipase,ATGL)是在脂滴上发现的水解甘油三酯的脂肪酶。除脂肪组织外,ATGL也广泛存在于骨骼肌等多种非脂肪组织中,并发挥着重要的生理功能。越来越多的研究表明,ATGL与中性脂质贮存异常、胰岛素抵抗等代谢疾病密切相关。运动可以通过改变ATGL的表达起到调控脂代谢的作用,进而在防治胰岛素抵抗等代谢疾病中发挥作用。 Lipid droplet, a cellular organelle for neutral lipid storage, is closely associated to insulin resistance and metabolic diseases. Adipose triglyceride lipase （ATGL） is an enzyme on lipid droplet, which is able to hydrolyze TAG. It is evident that the expression of ATGL is not restricted to adipose tissue but is also in many nonadipose tissues, such as skeletal muscle. Increasing studies suggest that ATGL might be related to neutral lipid storage disease and insulin resistance. The expression of ATGL can be regulated by endurance exercise training, and plays an important role in prevention and treatment of metabolic diseases such as insulin resistance.
作者 李璐 朱一力 张雪琳 刘平生
机构地区 首都体育学院运动科学与健康学院 中国科学院生物物理研究所
出处 《生物物理学报》 CAS CSCD 北大核心 2012年第7期583-592,共10页 Acta Biophysica Sinica
基金 国家自然科学基金项目(31100854) 北京市教育委员会科技计划面上项目(KM201110029004) 北京市属高等学校人才强教计划资助项目(PHR201108294)~~
关键词 脂肪甘油三酯水解酶 脂滴 骨骼肌 运动 胰岛素抵抗 Adipose triglyceride lipase Lipid droplet Skeletal muscle Exercise Insulin resistance
分类号 Q26 [生物学—细胞生物学] G804 [文化科学—运动人体科学]
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参考文献67

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同被引文献73

  • 1邹洪,汤礼军.脂肪甘油三醋脂酶与2型糖尿病胰岛素抵抗关系的研究现状[J].西南医学,2011,13(5):899-901.
  • 2Zechner R, Kienesberger PC, Haemmerle G, et al. Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores. J Lipid Res, 2009,50( 1 ) : 3-21.
  • 3Huijsman E,van de Par C,Economou C,et al. Adipose triacylglycerol lipase deletion alters whole body energy metabolism and impairs exercise performance in mice. Am J Physiol Endocrinol Metab,2009,297(2):E505-13.
  • 4Watt MJ,van Denderen BJ,Castelli LA,et al. Adipose triglyceride lipase regulation of skeletal muscle lipid metabolism and insulin responsiveness. Mol Endocrinol, 2008,22(5) :1200-1212.
  • 5Zimmermann R,Strauss JG,Haemmerle G,et al. Fat mo- bilization in adipose tissue is promoted by adipose triglyc- eride lipase. Science, 2004,306 (5700) : 1383-1386.
  • 6Jenkins CM,Mancuso DJ,Yan W,et al. Identification, cloning, expression ,and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacy- lase activities. J Biol Chem,2004,279(47) :48968-48975.
  • 7Villena JA, Roy S,Sarkadi -Nagy E,et al. Desnutrin,an adipoeyte gene encoding a novel patatin domain-contain- ing protein,is induced by fasting and glucocorticoids : ec- topic expression of desnutrin increases triglyceride hydrol- ysis. J Biol Chem,2004,279(45):47066-47075.
  • 8Haemmerle G,Lass A,Zimmermann R,et al. Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase. Science,2006,312 (5774) : 734-737.
  • 9Turpin SM,Hoy AJ,Brown RD,et al. Adipose triacylglyc- erol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice. Diabetologia,2011,54 (1):146-156.
  • 10Lee K,Shin J,Latshaw JD,et al. Cloning of adipose triglyceride lipase complementary deoxyribonucleic acid in poultry and expression of adipose triglyceride lipase during development of adipose in chickens. Pouh Sci,2009,88 (3) :620-630.

引证文献4

二级引证文献16

生物物理学报
2012年 第7期

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