摘要
目的比较氨溴索和猪肺磷脂注射液(PS)治疗足月新生儿呼吸窘迫综合征(NRDS)的临床疗效及安全性。方法将24例NRDS患儿随机分成两组,氨溴索组12例,30 mg/(kg.d),分4次静脉给药,连用3 d;PS组12例,予以气管内注入PS 100 mg/kg,观察两组患儿治疗前及治疗后6、12、24 h动脉血的pH、PaO2及PaCO2的水平、病情转归、住院时间、治疗过程中的并发症。结果氨溴索组及PS组患儿治疗后6 h、12 h的pH、PaO2及PaCO2改善水平的差异有统计学意义(P均<0.05),24 h pH、PaO2及PaCO2改善水平的差异无统计学意义(P均>0.05)。氨溴索组有效9例,无效3例,PS组有效11例,无效1例,有效率差异无统计学意义(P>0.05),两组均无死亡病例。并发症主要有肺出血、肺炎和颅内出血,两组住院时间和并发症的发生率差异均无统计学意义(P均>0.05)。结论氨溴索与PS治疗足月NRDS的效果相当,在一定程度上氨溴索可替代PS治疗。
Objective To compare the ambroxol and poractant alfa injection （PS） treatment by clinical effectiveness and safety on the term newborns with respiratory distress syndrome （NRDS）. Methods Twenty-four cases of the NRDS were divided into two groups at random, ambroxol group （12 cases）,use ambroxol 7.5 mg/kg, qid ivgtt, last 3 days;PS group （12 cases）, endotracheal injection PS 100 mg/kg. Observe the arterial blood pH, PaO2 and PaCO2 level in two groups of children before and 6, 12, 24 hours after the treatment, also the illness outcome, hospital stay, and the course of treatment complications. Results After the treatment for 6 h and 12 h, the levels＇ of the arterial blood pH, PaO2 and PaCO2 of the ambroxol group and PS group were improved, and the difference was statistically significant （P 〈 0.05）, the improve levels of 24 h＇s pH, PaO2 and PaCO2 were no statistically significant （P 〉 0.05）. Ambroxol group effective 9 cases, invalid in 3, PS group effective 11 patients, invalid in 1, the efficient difference was not statistically significant （P 〉 0.05）, both groups no deaths. Main complications including pulmonary hemorrhage, pneumonia and intracranial bleeding, two groups of the hospital stays and the incidence of complications were no statistically significant difference （P 〉 0.05）. Conclusion The effect of the ambroxol and PS treatment on NRDS are almost the same. To a certain extent, ambroxol alternative PS treatment.
出处
《中国现代医生》
2012年第19期53-54,57,共3页
China Modern Doctor
