摘要
目的探索重型肝炎患者并肝肾综合征(HRS)的危险因素,以便进行早期干预。方法回顾性收集145例重型肝炎患者的资料,对患者的生化指标和并发症进行单因素分析和多因素Logistic回归分析。结果重型肝炎并发HRS的发生率为28.3%(41/145)。多因素Logistic回归结果显示,进入回归方程的主要因素为:腹水(OR=9.02,95%CI:1.30～62.79)、血清尿素氮(OR=1.52,95%CI:1.13～2.07)、血清肌酐(OR=1.12,95%CI:1.09～1.16)、血氨(OR=1.05,95%CI:1.03～1.08)。结论重型肝炎并发HRS的患病率较高,积极预防腹水的发生,动态监测血清尿素氮、血清肌酐及血氨是预防HRS发生的重要措施。
Objective To investigate the risk factors of developing hepatorenal syndrome in patients with severe hepatitis to aid in design and implementation of preventive and early therapeutic strategies.Methods A total of 145 patients treated for severe hepatitis at our hospital between 2008 and 2011 were retrospectively analyzed.Laboratory indicators and complications were analyzed by Chi-squared test and multivariate logistic regression.Results The prevalence rate of hepatorenal syndrome among severe hepatitis patients was 28.3%（41/145）.Logistic regression analysis indicated that the risk factors of hepatorenal syndrome in patients with severe hepatitis were presence of ascites（odds ratio（OR）=9.02,95% confidence interval（CI）： 1.30-62.79） and perturbed levels of serum urea nitrogen（OR=1.52,95% CI： 1.13-2.07）,serum creatinine（OR=1.12,95% CI： 1.09-1.16）,and ammonia（OR=1.05,95% CI： 1.03-1.08）.Conclusion The prevalence rate of hepatorenal syndrome among severe hepatitis patients is high.Ascite formation,and levels of serum urea nitrogen,serum creatinine,and ammonia should be monitored regularly in patients with severe hepatitis to prevent and initiate early intervention to treat hepatorenal syndrome.
出处
《临床肝胆病杂志》
CAS
2012年第7期542-544,共3页
Journal of Clinical Hepatology
