摘要
目的:调查和分析上海市杨浦区市东医院临床分离的大肠埃希杆菌和肺炎克雷伯菌分布特征与药敏结果。方法:收集本院2010年临床送检标本所分离的大肠埃希杆菌和肺炎克雷伯菌药敏资料,用WHONET 5.5软件进行数据分析。结果:共获得大肠埃希杆菌696株和肺炎克雷伯菌409株,在菌株总数中排名第一和第三。大肠埃希杆菌检出率较高的科室为普外科(20.3%)、急诊科(14.1%)、风湿肾病科(12.6%),主要分离自尿(46.3%)、脓液(11.6%)和痰(10.8%)等标本。肺炎克雷伯菌检出率较高的科室为急诊科(17.6%)、呼吸科(14.2%)、肿瘤内科(11.7%),主要分离自痰(40.8%)、咽拭子(26.4%)和尿(9.5%)等标本。大肠埃希杆菌和肺炎克雷伯菌中产超广谱β-内酰胺酶(ESBLs)菌株检出率分别为56.0%和17.1%,两者的检出率之间具有显著性差异(P<0.01),产ESBLs菌株的耐药率明显高于非产ESBLs菌株。结论:本院大肠埃希杆菌和肺炎克雷伯菌在泌尿系统、呼吸系统疾病高发的科室分离率高,其耐药率水平主要受产ESBLs菌株的影响。
Objective： To investigate and analyse the distribution characteristics and results of antibacterial susceptibility of Escherichia coli and Klebsiella pneumoniae isolated from clinical specimens in Shidong Hospital of Shanghai Yangpu District. Methods： The data of antibacterial susceptibility of E coli and K pneumoniae isolated from clinical samples in 2010 in this hospital were collected and all the data were analyzed by WHONET 5.5 software. Results： A total of 696 strains of E coli and 409 strains of K pneumoniae were isolated, ranking the first and third in sum of all bacterial strains. The detection rates of E coli in the departments of general surgery （20.3%）, emergency （14. 1%） and rheumatism nephrology （12.6%） were high. E coli was mainly isolated from urine（46.3%）, pus（ll. 6%）, sputa（10.8%） and so on. The detection rates of K pneumoniae in the departments of emergency（ 17.6 % ）, respiratory diseases（ 14.2 % ） and oncology（ 11.7 % ） were high. K pneumonia were mainly isolated from sputa（40.8%）, throat swab（26.4%）, urine（9.5%） and so on. The detection rates of extended spectrum ]3-1actamases（ESBLs）-producing strains of E coli and K pneumoniae were 56.0 % and 17.1%, respectively. And there were significant differences between them（P〈0.01）. The drug-resistant rates of ESBLs-producing strains were higher than those of non-producing ESBLs strains. Conclusion： The isolation rates of E coli and K pneumoniae are high in the departments where the incidence rates of urinary tract system and respiratory system diseases are high in the hospital, and the drug-resistant rates are mainly affected by ESBLs-producing strains.
出处
《药学服务与研究》
CAS
CSCD
2012年第3期221-223,共3页
Pharmaceutical Care and Research
