摘要
目的探讨医院泌尿生殖道炎症患者支原体属感染特点及药物敏感现状,为临床抗菌药物治疗提供参考依据。方法采用解脲脲支原体(Uu)和人支原体(Mh)培养鉴定药敏试剂盒,对850例患者进行支原体属检测和药敏试验分析。结果支原体属检测总阳性率为57.5%,其中90.0%为单纯Uu感染,女性单纯Uu感染阳性率为60.2%与男性的23.8%相比,差异有统计学意义(P<0.01);单纯Uu、Mh感染及混合感染对多西环素、米诺环素和交沙霉素等3种抗菌药物的敏感性最强,敏感率均>65.0%;单纯Uu感染与Uu、Mh混合感染相比,前者对克拉霉素和阿奇霉素的敏感率分别为72.0%、66.6%,明显强于后者,差异有统计学意义(P<0.01),而后者对克拉霉素、罗红霉素、阿奇霉素、氧氟沙星、左氧氟沙星、司帕沙星等抗菌药物的耐药率均>50.0%,则明显强于前者,差异有统计学意义(P<0.01)。结论医院泌尿生殖道炎症患者以Uu感染为主,女性单纯Uu感染阳性率明显高于男性;治疗Uu、Mh及二者合并感染时应首选多西环素、米诺环素和交沙霉素,对单纯Uu感染还可考虑使用克拉霉素和阿奇霉素;临床医师应参考药敏结果合理选用抗菌药物。
OBJECTIVE To investigate the characteristics of Mycoplasma infections in patients with urogenital inflammation and the current status of drug susceptibility,to provide evidence for clinical use of antibiotics.METHODS By the means of susceptibility kit for culture and identification of Ureaplasma urealyticum（Uu）,Mycoplasma hominis（Mh）,detection of Mycoplasma from 850 patients and drug susceptibility testing were performed.RESULTS The total positive rate of Mycoplasma was 57.5%,among which 90.0% was Uu infection.The positive rate of Uu infection was 60.2% in female patients and 23.8% in male patients,the difference was statistically significant（P0.01）.The results of the drug susceptibility tests for 9 antibiotics showed that doxycycline,minocycline,and josamycin were the 3 most suscertible antibiotics for Uu infection,Mh infection,and coinfection with Uu and Mh,with the drug susceptibility rate higher than 65.0%.Compared with coinfection with Uu and Mh,the drug susceptibility rates of Uu infection alone to clarithromycin and azithromycin were 72.0% and 66.6% respectively,which were significantly higher（P0.01）;whereas the resistance rates of coinfection with Uu and Mh to clarithromycin,roxithromycin,azithromycin,ofloxacin,levofloxacin,and sparfloxacin were over 50.0% which were significantly higher（P0.01） than Uu infection alone.CONCLUSION Uu is the predominant pathogen causing infections in patients with urogenital inflammation in this region.The positive rate of Uu infection in female is significantly higher than that in male;doxycycline,minocycline,and josamycin should be taken as preferred treatment for Uu infection,Mh infection,or coinfeciton with Uu and Mh.For Uu infection alone,clarithromycin and azithromycin can also be taken,the clinicians can select antibiotics reasonably according to the results of drug susceptibility testing.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2012年第14期3188-3190,共3页
Chinese Journal of Nosocomiology
关键词
泌尿生殖道
支原体属
感染
药物敏感性
Urogenital tract
Mycoplasma
Infection
Drug susceptibility
