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Ⅲ型干扰素的抗肿瘤作用 被引量：2

The Anti-tumor Effects of Type Ⅲ Inteferons
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摘要 Ⅲ型干扰素(IFNλs)是干扰素家族中最新的一组成员。他们的很多生物学活性与临床上应用广泛的IFNα/β十分相似,但是他们所结合的受体与IFNα/β迥异。Ⅲ型干扰素的毒副作用显著小于IFNα/β,且抗肿瘤作用明显。本文回顾了近年来对Ⅲ型干扰素抗肿瘤功能研究的最新进展。 Type Ⅲ interferons（IFNλs） are the latest members of interferon family and share many biological activities with IFNα/β,but conduct signals through distinct receptor complexes.They have less severe side effects than IFNα/β and possess potent anti-tumor effects.Here we review the latest advances of studies upon the anti-tumor potentials of type Ⅲ interferons.
作者 李威 吴昊 张彤
机构地区 首都医科大学附属北京佑安医院感染科
出处 《现代生物医学进展》 CAS 2012年第17期3370-3373,共4页 Progress in Modern Biomedicine
基金 北京市属高等学校人才强教计划资助项目(PHR201007112) 艾滋病研究北京市重点实验室(BZ0089)
关键词 Ⅲ型干扰素 干扰素lambda 抗肿瘤 Type Ⅲ Interferon Interferon lambda Anti-tumor activity
分类号 R979.1 [医药卫生—药品] R978 [医药卫生—药品]
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参考文献33

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同被引文献38

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现代生物医学进展
2012年 第17期

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