摘要
目的探讨帕瑞昔布钠预防妇科腹腔镜手术患者瑞芬太尼麻醉后痛觉过敏的效应。方法选择ASAⅠ级妇科腹腔镜手术患者60例,随机均分为两组:帕瑞昔布钠组(P组)和对照组(C组)。观察患者术后拔管即刻(T0)、0.5h(T1)、1h(T2)、3h(T3)、6h(T4)、12h(T5)的MAP、HR、SpO2、RR、镇痛评分(VAS)、镇静评分(RSS),并记录患者的满意度、手术时间、手术结束至拔管的时间及术后不良反应。结果与C组比较,T0～T3时P组MAP显著下降、HR显著减慢(P<0.05)。与C组比较,T0～T4时P组VAS评分显著下降(P<0.01),RSS评分显著上升(P<0.01)。P组满意度显著高于C组(P<0.01)。两组手术时间、手术结束至拔管的时间和术后不良反应差异无统计学意义。结论帕瑞昔布钠能有效预防妇科腹腔镜手术患者瑞芬太尼麻醉后痛觉过敏,不增加不良反应。
Objective To investigate the preventive effect of parecoxib sodium on hyperalgesia induced by remifentanil-based anesthesia in the patients undergoing gynecological laparoscopic surgery. Methods Sixty ASA I patients scheduled for gynecological laparoscopic surgery were randomly divided into 2 groups： parecoxib group （group P, n=30） and control group （group C, n= 30）. MAP, HR, SpO2, RR, visual analogue scale （VAS）, and Ramsay sedation scale （RSS） of the patients at To, 0. 5 h（T1 ）, 1 h（T2）, 3 h（T3 ）, 6 h（T4 ） and 12 h（T5） were observed, the patient＇s satisfaction score, the duration time of surgery, the duration time from the end of surgery to extubation, and adverse effects after operation were also noted. Results MAP and HR in group P were significantly lower than those in group C at T0-T3 （P〈0. 05）. Compared with group C, VAS in group P decreased and RSS increased significantly at T0-T4 （P-〈0. 01）. The patient＇s satisfaction score in group P was significantly higher than that in group C （P〈0. 01）. No differences were observed in the duration time of surgery, the duration time from the end of surgery to extubation, and adverse effects after operation between two groups. Conclusion Parecoxib sodium were effective in preventing hyperalgesia induced by remifentanil-based anesthesia in the patients undergoing gynecological laparoscopic surgery, without increasing adverse events.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2012年第6期564-566,共3页
Journal of Clinical Anesthesiology
