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血清和肽素水平与心力衰竭程度及左室重构的相关性分析 被引量：11

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摘要 目的测定心力衰竭患者血清和肽素水平,探讨其与心力衰竭及心室重构程度的相关性。方法入选60例心力衰竭患者,其中缺血性心肌病(ICM)23例,扩张型心肌病(DCM)18例,高血压性心脏病(HHD)19例。依照NYHA分级分为两组,心功能Ⅲ级、Ⅳ级亚组各30例。另设健康对照组30名。测定所有入选者血清和肽素水平。结果心力衰竭组血清和肽素水平比健康对照组明显升高,且随心力衰竭程度的加重而增加;ICM组和肽素水平高于DCM组(P<0.05);和肽素水平与左室舒张末期内径(LVDd)呈正相关(β=0.372,P<0.001),和肽素水平与左室射血分数(LVEF)呈独立负相关(β=-0.388,P<0.001)。结论和肽素水平作为一个新的心力衰竭标志物,可以评估心力衰竭程度、判断心力衰竭预后,同时和肽素与左心室大小及心室重构相关,干预血管加压素(AVP)系统可能会有助于心力衰竭的治疗。
作者 耿圆圆 张雪娥
机构地区 山西医科大学第二医院
出处 《中西医结合心脑血管病杂志》 2012年第7期792-793,共2页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
关键词 和肽素 心力衰竭 心室功能不全 心室容积
分类号 R541.6 [医药卫生—心血管疾病] R256.2 [医药卫生—中医内科学]
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参考文献11

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二级参考文献34

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共引文献11

同被引文献106

  • 1李佐民.永久性心房纤颤伴长RR间期行单腔起搏器植入患者调低起搏下限频率对血浆脑钠肽水平的影响[J].黑龙江医药,2012,25(5):688-689. 被引量：2
  • 2王蓉.进行血NT-proBNP及尿酸联合检测在诊断老年慢性心力衰竭方面的临床价值分析[J].当代医药论丛,2014,12(6):59-60. 被引量：8
  • 3毛姗姗,叶菁菁,蒋国平,赵正言.定量组织速度成像和组织追踪显像技术评价先天性甲状腺功能减退症新生儿的右心功能[J].中华儿科杂志,2007,45(8):599-603. 被引量：9
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引证文献11

二级引证文献44

中西医结合心脑血管病杂志
2012年 第7期

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