摘要
目的探讨飞秒激光制瓣对准分子激光原位角膜磨镶术(LASIK)后角膜内皮细胞计数的影响。方法入选条件为自愿接受LASIK且经常规术前检查确认为适应证的患者,共284例,年龄18～45岁。根据术中角膜瓣制作方式不同分为S组(OUP板层角膜刀制瓣)和F组(飞秒激光制瓣)。分别在术前,术后1d、1周、1个月、3个月、6个月对术眼进行角膜内皮细胞密度检查,并记录数据分析。结果所有手术病例术中顺利,术后无并发症。内皮细胞密度:F组术后6个月同术前比较明显下降(P<0.05),余两组各时间点同术前比较差异均无统计学意义(P>0.05);术后6个月F组较S组明显下降(P<0.05),余各时间点两组间差异无统计学意义(P>0.05)。结论飞秒激光制瓣术后角膜内皮细胞密度较机械板层刀制瓣的LASIK低,其机制有待进一步研究。
Objective To evaluate the effects of femtosecond laser assisted in situ keratomileusis on corneal en- dothelial cell density（ECD）. Methods Two hundred and eighty-four cases, aged 18 to 45 , were enrolled. They under- went routine preoperative examinations and accepted LASIK surgeries. Patients were separated into 2 groups： S group （ cornea flap was made with a One Use Plus mechanical microkeratome） and F group （cornea flap was made with a femto- second laser）. Corneal ECD was obtained preoperatively and postoperatively. Results There was no complications in all patients during and after surgery. There was no statistical difference of ECD in group S postoperatively and preoperatively （P 〉 0.05 ）. However six months after surgery ECD was significantly decreased compared with that before surgery in group F （P 〈 0.05）. There was no statistical difference of ECD between these two groups within three months after sur- gery （P 〉 0.05）. ECD of group F at the six months after surgery was significantly decreased compared with that of group S. Conclusions ECD was lower after LASIK whose corneal flap was produced with a femtosecond laser than that with an One Use Plus mechanical microkeratome. （Chin J Ophthalmol and Otorhinolaryngol,2012,12：234-236）
出处
《中国眼耳鼻喉科杂志》
2012年第4期234-236,共3页
Chinese Journal of Ophthalmology and Otorhinolaryngology
