摘要
目的测定变应性鼻炎(AR)患者血清IgE及补体C3含量,分析IgE及补体C3与变应性鼻炎是否存在相关性。方法常年性变应性鼻炎(PAR)患者100例,季节性变应性鼻炎(SAR)患者100例,健康对照人群100例。用速率散射比浊法测定IgE及补体C3含量。PAR组又分为初发未用药组、1年病史组、3年病史组和药物干预组,再按轻度和中重度进行分组测定。结果 SAR组、PAR组及健康人群的IgE平均值差异有统计学意义,SAR组最高。SAR组和健康人群组的C3值差异无统计学意义,PAR组与健康对照组、PAR组与SAR组C3值,差异均有统计学意义。PAR组内,1年病史组与3年病史组C3值差异无统计学意义;轻度和中重度患者的IgE及补体C3比较,差异有统计学意义。结论 AR患者IgE明显高于健康人群。PAR患者血清补体C3下降程度高于SAR患者及健康人群。AR患者IgE及补体C3在发病初期较高,随时间推移而下降。药物干预对控制IgE及补体C3有较好效果。
Objective To determine the serum immunoglobin E （IgE） and complement 3c （C3） in patients with allergic rhinitis （AR）, and to analyze the correlations between IgE, C3 and AR. Methods One hundred perennial AR （PAR） patients, 100 seasonal AR（SAR） patients and 100 healthy people were included in the study. Rate nephelometry was used to determine the IgE and C3 content. The PAR patients were divided into new-onset of non-treatment group, case history for 1 year group and 3 years group, and intervention with medicine group. In addition, all patients were divided into mild and moderate to severe group. Results Significant difference was observed in IgE among the three groups, with the highest content observed in SAR. There was no significant difference in C3 between SAR group and the healthy group but significant between PAR and SAR as well as PAR and the healthy group. In the PAR group, no signifi- cant difference was observed in C3 between 1 year case history group and 3 years case history group. Significant differences in IgE and C3 were observed between the mild and moderate-to-severe group. Conclusions IgE was signifi- cantly higher in AR patients than that in the healthy people. Serum C3 decreased obviously in PAR patients than that in SAR patients and healthy people. IgE and C3 was higher in the early period of the case history and declined over time. Drug intervention was helpful to the control of IgE and C3. （Chin J Ophthalmol and Otorhinolarvngol ,2012 ,12 ：229-231 ）
出处
《中国眼耳鼻喉科杂志》
2012年第4期229-231,共3页
Chinese Journal of Ophthalmology and Otorhinolaryngology
