摘要
目的探讨莫西沙星(MFX)及左氧氟沙星(LFX)对耐多药结核分枝杆菌(MDR-TB)临床分离株的体外抗菌活性。方法选取171株MDR-TB临床分离株,以试管二倍稀释法采用7H9培养基,测定对MXF和LVF的MIC。结果 171株中47株(27.49%)对LVF低耐药(MIC为1～8 ug/ml),对MXF不耐药(MIC为≤1 ug/ml);20株(11.70%)对LVF高耐药(MIC为>8 ug/ml),对MXF部分耐药(MIC为1～4 ug/ml)。结论在目前MDR-TB临床分离株中,LFX已出现较高的耐药率,MFX较LFX的抗结核活性强4～8倍,为不完全交叉耐药。
Objective To study the effects of moxofloxacin （MFX） and levofloxacin （LFX） on antibacterial activity of clinical i- solated strains of multidrug mycobacterium tuberculosis in vitro. Methods 171 clinical isolated strains of MDR-TB were studied. The MICs to MFX and LFX were determined by test tube doubling dilution method on 7H9 culture media. Results Among the 171 isolated strains of MDR-TB, 47 （27.94%） low-resistant to LFX （ MIC ： 1 - 8 ug/ml）, but sensitive （ MIC ≤ 1 ug/ml） to MFX;20 isolated strains of MDR-TB high-resistant （ MIC 〉 8 ug/ml） to LFX, while most resistant （ MIC ： 1 - 4 ug/ml） to MFX. Conclusions There are high re- sistant ratio of LFX in isolated strains of MDR-TB. The MICs of MXF were 4 - 8 times stronger than that of LFX, and they have not com- pletely cross-resistance. The clinical doctors need to pay more attention on this phenomenon.
出处
《临床肺科杂志》
2012年第8期1435-1436,共2页
Journal of Clinical Pulmonary Medicine
基金
江苏省南通市科技局立项课题(指令性社会发展科技计划编号:S2010038)
