摘要
目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)合并高血糖患者血清抵抗素、TNF-α的含量变化及其意义。方法 46例AECOPD患者按照血糖标准分为高血糖组20例和非高血糖组26例,分别测定血清抵抗素、TNF-α,并计算胰岛素抵抗指数(HOMA-IR),同时与20例健康体检者比较。结果高血糖组的HOMA-IR,抵抗素及TNF-α与非高血糖组和对照组比较差异均有统计学意义。相关分析发现血清抵抗素水平与HOMA-IR、TNF-α呈正相关(r值分别为0.358、0.689,P<0.05)。结论 AECOPD合并糖代谢异常患者中,抵抗素参与了胰岛素抵抗,但其主要可能作为炎症因子参与高血糖的发生。
Objective To explore hyperglycemia in patients with AECOPD Serum resistin, TNF - α levels and its significance. Methods 46 cases of patients with AECOPD in accordance with glucose standards are divided into patients with high blood sugar （ n = 20） and non - hyperglycemic group （ n = 26）, the serum resistin and TNF - a were determined, and calculated insulin resistance index （ HOMA - IR）. Results Compared with the control group Hyperglycemia of HOMA - IR, resistin and TNF -α significantly changed in non - hyperglycemic group. Resistin concentration was positive correlated with HOMA - IR, TNF - α （ respectively r = 0. 358, 0. 689, P 〈 0. 05 ）. Conclusion AECOPD patients with abnormal glucose metabolism in the merger, resistin in insulin resistance, but the main factor involved in inflammation, which may as the incidence of hyperglycemia.
出处
《宁夏医学杂志》
CAS
2012年第6期504-505,共2页
Ningxia Medical Journal
基金
宁夏自然科学基金资助项目(NZ08125)
