摘要
本文对10例NIDDM患者的黎明现象进行了观察。受试者在常规饮食和口服降糖药的情况下,于0:00～8:00时每小时抽血一次,测定BG、F、GH、GG和INS,并于0:00、3:00、5:00、8:00时分别采血测定ACTH。如按凌晨BG上升至少大于1mmol/L作为黎明现象的判定标准,则本组出现这种现象的频率为6/10。本观察结果提示,在常规治疗的NIDDM患者中,黎明现象也常见到。胰岛素作用缺乏和对抗激素F升高,可能在黎明现象的发生机理中起作用。
The dawn phenomenon and its frequency in 10 NIDDM patients on conventional therapy were studied. Blood samples were taken hourly from 2400 to 0800 h for BG, F, GH, GG and INS. ACTH was measured at 2400, 0300, 0500 and 0800 h respectively. If we defined the dawn phenomenon as a rise of BG beyond 1.0 mmol/L in early morning, then 6/10 patients exhibited this phenomenon. Thus the dawn phenomenon occurs commonly in NIDDM patients treated with conventional therapy. The result of this study suggested that the deficiency of insulin effect and the increased level of counterregulatory hormone-F may play a role in the pathogenesis of dawn phenomenon of NIDDM patients.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
1990年第3期137-139,共3页
Chinese Journal of Endocrinology and Metabolism
关键词
糖尿病
非胰岛素型
黎明现象
Non-insulin-dependent diabetes mellitus Dawn phenomenon
