摘要
目的 对国产８ 个厂家的９ 批普萘洛尔片剂进行了体外溶出度测定，并比较不同溶出测定方法对其溶出参数（Ｔ５０ ，Ｔｄ）的影响。方法 采用分光光度法测定普萘洛尔片剂的体外溶出度，分别使用浆法和转蓝法，对溶出参数进行了统计学处理。结果 不同厂家的片剂之间，浆法测定的溶出参数均有显著性差别（ Ｐ＜０ ．０１） ，而转蓝法测定结果相似。结论 浆法较转蓝法更能准确反映普萘洛尔片剂的内在质量。
ObjectiveThe dissolution of propranolol hydrochloride tablets manufactured by eight different factories was tested,the effect of two dissolutive assay methods on dissolution was compared.MethodsThe dissolution of propranolol hydrochloride tablets was analyzed with spectrophotometry,one method was with a dissolutive apparatus Ⅱ,and the other with dissolutive apparatus Ⅰ. According to the dissolution rate of each tablet,the dissolutive parameters of different products were processed with satistical analytics.ResultsThe dissolutive parameters with dissolutive apparatus Ⅱ had significant difference (P< 0.01 ),but that with dissolutive apparatus Ⅰhad no difference.ConclusionThe quality of propranolol hydrochloride tablets is more exact with dissolutive apparatus Ⅱthan with dissolutive apparatus Ⅰ.
出处
《河北医科大学学报》
CAS
2000年第1期26-28,共3页
Journal of Hebei Medical University
关键词
普萘洛尔
紫外分光光度法
片剂
溶出度
propranolol/anal
spectrophotometry,ultraviolet/methods
dissolution
