摘要
目的探讨含左氧氟沙星的四联疗法补救治疗幽门螺杆菌的疗效及安全性。方法 120例经抗Hp治疗失败的患者分为观察组与对照组各60例,观察组给予PPI+左氧氟沙星+枸橼酸铋钾+阿莫西林四联方案治疗,对照组给予雷贝拉唑+克拉霉素+阿莫西林的三联方案治疗,对比两组Hp根除率及其不良反应发生率。结果观察组根除率(93.3%)显著高于对照组(78.3%)(P<0.05),两组不良反应发生率比较差异无统计学一样(P>0.05)。结论 PPI+左氧氟沙星+枸橼酸铋钾+阿莫西林四联方案补救治疗Hp感染根除率高,不良反应少,可在临床推广应用。
Objective To discuss the effects and safety of levofloxacin-based quadruple therapy for Helicobacter pylori infection.Methods One hundred and twenty patients with Helicobacter pylori infection undergoing virologic failure were divided into two groups.The observation group（60 cases） was treated with quadruple regimen：PPI ＋Levofloxacin ＋ Folic Acid Aismuth K ＋ Amoxicillin,while the control group（60 cases） was treated with triple regimen：Rabeprazole＋Clarithromycin＋Amoxicillin.Then the eradication rate of Helicobacter pylori and adverse reactions were compared between the two groups.Results The eradication rate of Helicobacter pylori in the observation group（93.3%） was significantly higher than that in the control group（78.3%）,P〈0.05.But no statistically significant differences were found on the adverse reactions between the two groups（P〉0.05）.Conclusion Levofloxacin-based quadruple therapy for Helicobacter pylori infection has high eradication rate and less adverse reactions,which is worthy to be popularized in clinical practice.
出处
《海南医学》
CAS
2012年第13期35-36,共2页
Hainan Medical Journal
关键词
左氧氟沙星
四联方案
幽门螺杆菌
Levofloxacin； Quadruple therapy； Helicobacter pylori
