摘要
目的：为了观察ＣＤＫ４和ｐ１６蛋白在鼻咽癌组织中的表达状态，探讨其与鼻咽癌的发生、发展关系。方法：应用Ｓ－Ｐ免疫组化法检测ＣＤＫ４和ｐ１６蛋白在６０例鼻咽癌和２０例正常鼻咽部粘膜组织中的表达。结果：６０例鼻咽癌中 ＣＤＫ４和ｐ１６蛋白表达率分别为６６．７％和２３．３％。高分化鳞癌ｐ１６蛋白的表达率明显高于低分化鳞癌（Ｐ＜ ０． ０１）。 ２１例淋巴结转移阳性组中ｐ１６蛋白的表达率低于 １４例阴性组（Ｐ＜ ０． ０５），而ＣＤＫ４蛋白表达率高于阴性组（Ｐ＜ ０．０５）。结论：提示ＣＤＫ４蛋白的过度表达与ｐ１６蛋白的低表达可能涉及鼻咽癌的发生、发展过程。ｐ１６蛋白的表达缺失与鼻咽癌细胞分化、转移有关。ＣＤＫ４蛋白的过度表达与鼻咽癌的转移有关。
Objective: To evaluate the role of CDK4 and p16 protein expression in nasopharyngeal carcinoma (NPC). Methods: The S-P immunohistochemical method was used to detect the expression of CDK4 and p16 protein in 60 cases of NPC and 20 cases of normal tissues. Results:The positive expression rates of CDK4 and p16 protein in NPC were 66. 7% and 23. 3%, respectively. The positive expression rate of p16 protein was higher in well differentiated squamous cell carcinoma than in poorly differentiated squamous cell carcinoma (P <0. 01 ). A significant correlation was found between low expression of p16 protein, over expression of CDK4 protein and cervical lymph node metastasis (P < 0.05 ). Conclusions: The results suggest that the inactivation of p16 protein and over expression of CDK4 protein may be involved in the carcinogenesis and development of NPC and implicated in tumor defferentiation and metastasis.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2000年第1期34-36,共3页
Chinese Journal of Cancer
关键词
鼻咽肿瘤
CDK4
P16蛋白
Nasophalyneal carcinoma
Immunohistochemistry
CDK4
p16
