摘要
目的 :观察葛根素对慢性心力衰竭患者心功能及氧化型低密度脂蛋白 (ox LDL)的影响。方法 :选择 1 997～ 1 998年我科住院的 78例慢性心力衰竭患者 ,随机分为常规治疗组 (简称常规组 )和常规 +葛根素治疗组 (简称葛根素组 ) ,所有病人均给予强心、利尿、扩张血管等常规治疗 ,葛根素组加用葛根素 40 0mg·d- 1 ,疗程为 1 0d。结果 :治疗后 ,两组病人临床心功能均有改善 ,但两组差异无显著性 (P >0 .0 5) ,葛根素组治疗后左室射血分数提高明显好于常规组 ,且差异有显著性 (P <0 .0 5)。同时 ,葛根素组治疗前、后对照 ,ox LDL降低差异有显著性 (P <0 .0 5) ,而常规组治疗前、后对照ox LDL差异无显著性 (P >0 .0 5) .结论 :葛根素对于慢性心力衰竭病人有改善心功能、提高射血分数的作用 ,同时 ,能降低血清ox
Objective: To observe the effect of puerarin on heart function and serum oxidized LDL(ox LDL) in patients with chronic cardiac failure. Methods: Seventy eight patients with chronic cardiac failure were randomly divided into two groups, regular group (R) and regular+puerarin group (P). All patients in two groups received conventional treatment with inotropic agents, diuretic, and vasodilator, etc. The patients in the P group took puerarin 400 mg·d -1 for 10 days. Results: After treatment, the clinical heart function of the patients in the two groups was improved, but there was no significant difference between them; the left ventricular ejection fraction (EF) of patients in the P group was higher than that in the R group(P<0.05); and serum ox LDL level was significantly decreased in the P group patients, but that was no change in the R group patients(P<0.05). Conclusion: Puerarin may improve the clinical heart function, increase the left ventricular ejection, meanwhile, it may decrease the level of ox LDL. [
出处
《湖南医科大学学报》
CSCD
2000年第2期176-178,共3页
Bulletin of Hunan Medical University
关键词
葛根素
慢性心力衰竭
低密度脂蛋白类
puerarin
chronic cardiac failure~*
ventricular function,left
lipoproteins,LDL
