摘要
通过四氧嘧啶 链脲霉素联合给药 ,探讨其对狗I型糖尿病动物模型的成模效率以及对实验动物的毒副作用。用药 7～ 1 4d后 5/ 6只雄性狗的血糖持续维持在高血糖状态 ,平均达 (2 2 .7± 3.2 )mmol·L- 1 ,胰岛素用量从 2U·d- 1 增至 (2 1 .4± 2 .4)U·d- 1 。 3只雌性动物在用药后 7d内死亡。结果提示 ,四氧嘧啶 链脲霉素联合用药可减少二者单用时的剂量 ,从而降低毒副作用 ;这种联合用药是建立I型糖尿病模型较好的化学诱导方法 ,具有成模率高等特点 。
To evaluate the efficiency and toxic and side effect of the combined chemical inducer for TypeⅠdiabetes mellitus, TypeⅠdiabetes in 9 adult dogs were induced with alloxan(50 mg·kg -1 ) and streptozotocin(30 mg·kg -1 ) with vein injection. After 7～14 days, the blood glucose of 5 male dogs was kept on high levels [ mean value was (22.7±3.2) mmol·L -1 ], exogenous insulin was (21.4±2.4) U·day -1 . Three female dogs died in 7 days after they had been injected with the combined inducers. Alloxan streptozotocin combination administration reduced the dosage of each drug, and decreased the toxic and side effect of each drug. The results suggest that this method has a high rate of success to induce TypeⅠdiabetes male dogs. [
出处
《湖南医科大学学报》
CSCD
2000年第2期125-128,共4页
Bulletin of Hunan Medical University
基金
国家自然科学基金资助项目! ( 39770 2 33)
关键词
Ⅰ型糖尿病
药物协同作用
联合给药
疾病模型
streptozotocin
alloxan
drug synergish
diabetes mellitus
drug therapy
disease models,animal
dogs
