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PI3K-Akt-mTOR信号通路与病毒性心肌炎 被引量：2

PI3K–Akt–mTOR signal pathway and viral myocarditis
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摘要 PI3K-Akt-mTOR是细胞内重要的信号通路,在细胞凋亡、转录、翻译、代谢、血管新生及细胞周期等过程发挥着重要作用。柯萨奇病毒B组3型(coxsackievirus B3,CVB3)导致的病毒性心肌炎是小儿常见的后天性心脏病,大部分非由病毒直接破坏所致,而涉及免疫反应与细胞凋亡。阐明CVB3感染细胞后PI3K-Akt-mTOR信号通路的变化,有助于揭示病毒性心肌炎的发病机制,对心肌炎的治疗与预后起重要作用。 The PI3K-Akt-mTOR signal pathway is a key intracellular signal transduction pathway, which plays important roles in cell apoptosis, transcription, translation, metabolism, angiogenesis, and the cell replication cycle. Viral myocarditis, resulting from coxsackievirus B3, primarily involves the immune response and apoptosis rather than cellular damage by the virus per se. It is a commonly acquired heart disease in children. We elucidate changes in the PI3K-Akt-mTOR signal pathway in cells infected by coxsackievirus B3 which contribute to the pathogenesis of viral myocarditis.
作者 陈志衡 杨作成
机构地区 中南大学湘雅三医院儿科
出处 《国际病理科学与临床杂志》 CAS 2012年第3期226-230,共5页 Journal of International Pathology and Clinical Medicine
基金 国家自然科学基金(30973233)~~
关键词 信号通路 凋亡 病毒性心肌炎 signal pathway apoptosis viral myocarditis
分类号 R725.4 [医药卫生—儿科]
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共引文献126

同被引文献28

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国际病理科学与临床杂志
2012年 第3期

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